Position-independent, high-level expression of the human beta-globin gene in transgenic mice.

Position-independent, high-level expression of the human beta-globin gene in transgenic mice.

We have constructed a "minilocus" that contains the 5' and 3' flanking regions of the human beta-globin locus and the beta-globin gene. These regions are characterized by erythroid-specific DNAase I-superhypersensitive sites and are normally located approximately 50 kb 5' an...

ver descrição completa

Detalhes bibliográficos
Principais autores:	Grosveld, F, van Assendelft, G, Greaves, D, Kollias, G
Formato:	Journal article
Idioma:	English
Publicado em:	1987

Registros relacionados

REGULATION OF EXPRESSION FROM THE HUMAN BETA-GLOBIN GENE DOMAIN
por: Antoniou, M, et al.
Publicado em: (1988)

High-level, erythroid-specific expression of the human alpha-globin gene in transgenic mice and the production of human hemoglobin in murine erythrocytes.
por: Hanscombe, O, et al.
Publicado em: (1989)

The beta-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner.
por: Blom van Assendelft, G, et al.
Publicado em: (1989)

The beta-globin dominant control region.
por: Greaves, D, et al.
Publicado em: (1989)

A dominant control region from the human beta-globin locus conferring integration site-independent gene expression.
por: Talbot, D, et al.
Publicado em: (1989)

Human CD2 3'-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice.
por: Greaves, D, et al.
Publicado em: (1989)

The developmental regulation of the human zeta-globin gene in transgenic mice employing beta-galactosidase as a reporter gene.
por: Pondel, MD, et al.
Publicado em: (1992)

Analysis of the human alpha-globin gene cluster in transgenic mice.
por: Sharpe, J, et al.
Publicado em: (1993)

5' structural motifs and Xenopus beta globin gene activation.
por: Brewer, A, et al.
Publicado em: (1988)

Proximal promoter elements of the human zeta-globin gene confer embryonic-specific expression on a linked reporter gene in transgenic mice.
por: Pondel, MD, et al.
Publicado em: (1996)

GEOGRAPHIC-DISTRIBUTION OF ALPHA-GLOBIN AND BETA-GLOBIN GENE-CLUSTER POLYMORPHISMS
por: Wainscoat, J, et al.
Publicado em: (1989)

RecBC, sbcB independent, (AT)n-mediated deletion of sequences flanking a Xenopus laevis beta globin gene on propagation in E. coli.
por: Greaves, D, et al.
Publicado em: (1986)

Tau phosphorylation in transgenic mice expressing glycogen synthase kinase-3beta transgenes.
por: Brownlees, J, et al.
Publicado em: (1997)

Analysis of the human alpha globin upstream regulatory element (HS-40) in transgenic mice.
por: Sharpe, J, et al.
Publicado em: (1992)

Globin gene switching: a paradigm or what?
por: Enver, T, et al.
Publicado em: (1991)

A silent deletion in the beta-globin gene cluster.
por: Tate, V, et al.
Publicado em: (1986)

Intergenic transcription in the human beta-globin gene cluster.
por: Plant, K, et al.
Publicado em: (2001)

The structure and evolution of the human beta-globin gene family.
por: Efstratiadis, A, et al.
Publicado em: (1980)

Modification of human beta-globin locus PAC clones by homologous recombination in Escherichia coli.
por: Imam, A, et al.
Publicado em: (2000)

The human lysozyme promoter directs reporter gene expression to activated myelomonocytic cells in transgenic mice.
por: Clarke, S, et al.
Publicado em: (1996)

The evolution of the alpha- and beta-globin gene clusters in human populations.
por: Hill, A, et al.
Publicado em: (1986)

Correlation of BACH1 and hemoglobin E/Beta-thalassemia globin expression
por: Tze, Yan Lee, et al.
Publicado em: (2016)

The Effect of Resveratrol on Gamma Globin Gene Expression in Patients with Beta Thalassemia: The Role of Adaptation to Cellular Stress
por: Hossein Jalali, et al.
Publicado em: (2024-09-01)

Replication, methylation, and expression of X laevis globin genes injected into fertilized Xenopus eggs.
por: Williams, J, et al.
Publicado em: (1983)

SPECTRUM OF BETA GLOBIN GENE MUTATIONS IN EGYPTIAN CHILDREN WITH β- THALASSEMIA
por: MR El-Shanshory, et al.
Publicado em: (2014-08-01)

Alpha globin gene alterations modifying the phenotype of homozygous beta thalassaemia
por: Jyoti Shaw, et al.
Publicado em: (2024-06-01)

Multiple origins of the sickle mutation: evidence from beta S globin gene cluster polymorphisms.
por: Wainscoat, J, et al.
Publicado em: (1983)

CHARACTERIZATION OF BETA-GLOBIN MESSENGER-RNA IN BETA-O THALASSEMIAS
por: Old, J, et al.
Publicado em: (1978)

Characterization of beta-globin mRNA in the beta0 thalassemias.
por: Old, J, et al.
Publicado em: (1978)

Long-range regulation of alpha-globin gene expression.
por: Higgs, D, et al.
Publicado em: (2008)

Evaluation of Beta Globin Gene Mutations in Beta Thalassemia Carrier Children in Aydın Province and its Environment
por: Deniz Ilgün, et al.
Publicado em: (2021-03-01)

The spectrum of beta-globin gene mutations in children with beta-thalassaemia major from Kota Kinabalu, Sabah, Malaysia
por: Thong, M.K., et al.
Publicado em: (2005)

BETA-GLOBIN GENE MUTATIONS IN TURKISH CHILDREN WITH BETA-THALASSEMIA: RESULTS FROM A SINGLE CENTER STUDY
por: Ali Fettah, et al.
Publicado em: (2013-09-01)

Ameliorating β-thalassaemia by manipulating expression of the α-globin gene
por: Mettananda, S
Publicado em: (2015)

Dicer-dependent turnover of intergenic transcripts from the human beta-globin gene cluster.
por: Haussecker, D, et al.
Publicado em: (2005)

The organization of the tadpole and adult alpha globin genes of Xenopus laevis.
por: Patient, R, et al.
Publicado em: (1982)

The regulation of ζ-globin expression
por: King, A
Publicado em: (2019)

Intergenic transcription and transinduction of the human beta-globin locus.
por: Ashe, H, et al.
Publicado em: (1997)

Allelic sequence diversity at the human beta-globin locus
por: Fullerton, S, et al.
Publicado em: (1994)

Identification of mutations in a trans-acting factor with different effects on alpha and beta globin expression.
por: Viprakasit, V, et al.
Publicado em: (2000)