Position-independent, high-level expression of the human beta-globin gene in transgenic mice.
We have constructed a "minilocus" that contains the 5' and 3' flanking regions of the human beta-globin locus and the beta-globin gene. These regions are characterized by erythroid-specific DNAase I-superhypersensitive sites and are normally located approximately 50 kb 5' an...
Main Authors: | Grosveld, F, van Assendelft, G, Greaves, D, Kollias, G |
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格式: | Journal article |
语言: | English |
出版: |
1987
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