Myeloid cell interferon secretion restricts Zika flavivirus infection of developing and malignant human neural progenitor cells

Myeloid cell interferon secretion restricts Zika flavivirus infection of developing and malignant human neural progenitor cells

Zika virus (ZIKV) can infect human developing brain (HDB) progenitors resulting in epidemic microcephaly, whereas analogous cellular tropism offers treatment potential for the adult brain cancer, glioblastoma (GBM). We compared productive ZIKV infection in HDB and GBM primary tissue explants that bo...

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Bibliographic Details
Main Authors: Bulstrode, H, Girdler, GC, Gracia, T, Aivazidis, A, Moutsopoulos, I, Young, AMH, Hancock, J, He, X, Ridley, K, Xu, Z, Stockley, JH, Finlay, J, Hallou, C, Fajardo, T, Fountain, DM, van Dongen, S, Joannides, A, Morris, R, Mair, R, Watts, C, Santarius, T, Price, SJ, Hutchinson, PJA, Hodson, EJ, Pollard, SM, Mohorianu, I, Barker, RA, Sweeney, TR, Bayraktar, O, Gergely, F, Rowitch, DH
Format: Journal article
Language:English
Published: Cell Press 2022

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