Association of anthropometry and weight change with risk of dementia and its major subtypes: a meta-analysis consisting 2.8 million adults with 57,294 cases of dementia
Uncertainty exists regarding the relation of body size and weight change with dementia risk. As populations continue to age and the global obesity epidemic shows no sign of waning, reliable quantification of such associations is important. We examined the relationship of body mass index, waist circu...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Wiley
2020
|
| _version_ | 1797060792463392768 |
|---|---|
| author | ManYing, C Woodward, M Batty, D |
| author_facet | ManYing, C Woodward, M Batty, D |
| author_sort | ManYing, C |
| collection | OXFORD |
| description | Uncertainty exists regarding the relation of body size and weight change with dementia risk. As populations continue to age and the global obesity epidemic shows no sign of waning, reliable quantification of such associations is important. We examined the relationship of body mass index, waist circumference, and annual percent weight change with risk of dementia and its subtypes by pooling data from 19 prospective cohort studies and four clinical trials using meta-analysis. Compared with body mass index-defined lower-normal weight (18.5–22.4 kg/m2), the risk of all-cause dementia was higher among underweight individuals but lower among those with upper-normal (22.5–24.9 kg/m2) levels. Obesity was associated with higher risk in vascular dementia. Similarly, relative to the lowest fifth of waist circumference, those in the highest fifth had non-significant higher vascular dementia risk. Weight loss was associated with higher all-cause dementia risk relative to weight maintenance. Weight gain was weakly associated with higher vascular dementia risk. The relationship between body size, weight change and dementia is complex and exhibits nonlinear associations depending on dementia subtype under scrutiny. Weight loss was associated with an elevated risk most likely due to reverse causality and/or pathophysiological changes in the brain, although the latter remains speculative. |
| first_indexed | 2024-03-06T20:21:55Z |
| format | Journal article |
| id | oxford-uuid:2e183111-0a40-4930-bba3-7b63dfbb637c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:21:55Z |
| publishDate | 2020 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:2e183111-0a40-4930-bba3-7b63dfbb637c2022-03-26T12:47:00ZAssociation of anthropometry and weight change with risk of dementia and its major subtypes: a meta-analysis consisting 2.8 million adults with 57,294 cases of dementiaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2e183111-0a40-4930-bba3-7b63dfbb637cEnglishSymplectic Elements at OxfordWiley2020ManYing, CWoodward, MBatty, DUncertainty exists regarding the relation of body size and weight change with dementia risk. As populations continue to age and the global obesity epidemic shows no sign of waning, reliable quantification of such associations is important. We examined the relationship of body mass index, waist circumference, and annual percent weight change with risk of dementia and its subtypes by pooling data from 19 prospective cohort studies and four clinical trials using meta-analysis. Compared with body mass index-defined lower-normal weight (18.5–22.4 kg/m2), the risk of all-cause dementia was higher among underweight individuals but lower among those with upper-normal (22.5–24.9 kg/m2) levels. Obesity was associated with higher risk in vascular dementia. Similarly, relative to the lowest fifth of waist circumference, those in the highest fifth had non-significant higher vascular dementia risk. Weight loss was associated with higher all-cause dementia risk relative to weight maintenance. Weight gain was weakly associated with higher vascular dementia risk. The relationship between body size, weight change and dementia is complex and exhibits nonlinear associations depending on dementia subtype under scrutiny. Weight loss was associated with an elevated risk most likely due to reverse causality and/or pathophysiological changes in the brain, although the latter remains speculative. |
| spellingShingle | ManYing, C Woodward, M Batty, D Association of anthropometry and weight change with risk of dementia and its major subtypes: a meta-analysis consisting 2.8 million adults with 57,294 cases of dementia |
| title | Association of anthropometry and weight change with risk of dementia and its major subtypes: a meta-analysis consisting 2.8 million adults with 57,294 cases of dementia |
| title_full | Association of anthropometry and weight change with risk of dementia and its major subtypes: a meta-analysis consisting 2.8 million adults with 57,294 cases of dementia |
| title_fullStr | Association of anthropometry and weight change with risk of dementia and its major subtypes: a meta-analysis consisting 2.8 million adults with 57,294 cases of dementia |
| title_full_unstemmed | Association of anthropometry and weight change with risk of dementia and its major subtypes: a meta-analysis consisting 2.8 million adults with 57,294 cases of dementia |
| title_short | Association of anthropometry and weight change with risk of dementia and its major subtypes: a meta-analysis consisting 2.8 million adults with 57,294 cases of dementia |
| title_sort | association of anthropometry and weight change with risk of dementia and its major subtypes a meta analysis consisting 2 8 million adults with 57 294 cases of dementia |
| work_keys_str_mv | AT manyingc associationofanthropometryandweightchangewithriskofdementiaanditsmajorsubtypesametaanalysisconsisting28millionadultswith57294casesofdementia AT woodwardm associationofanthropometryandweightchangewithriskofdementiaanditsmajorsubtypesametaanalysisconsisting28millionadultswith57294casesofdementia AT battyd associationofanthropometryandweightchangewithriskofdementiaanditsmajorsubtypesametaanalysisconsisting28millionadultswith57294casesofdementia |