A modular, enantioselective synthesis of resolvins D3, E1, and hybrids

Resolvins D3 and E1 are important signaling molecules in the resolution of inflammation. Here, we report a convergent and flexible strategy to prepare these natural products using Hiyama-Denmark coupling of five- and six-membered cyclic alkenylsiloxanes to connect three resolvin fragments, and contr...

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Hlavní autoři: Urbitsch, F, Elbert, BL, Llaveria, J, Streatfeild, PE, Anderson, EA
Médium: Journal article
Jazyk:English
Vydáno: American Chemical Society 2020