CLIPPERS: a case report with radiology, three serial biopsies and a literature review
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a rare central nervous system inflammatory disorder primarily affecting the brainstem and cerebellum. We report a case of CLIPPERS in a 45-year-old man presenting with left facial numbness and...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Dustri-Verlag
2019
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| _version_ | 1797060804959272960 |
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| author | Turnquist, C Pretorius, PM Deluca, GC Halliday, J Kerr, R Hofer, M |
| author_facet | Turnquist, C Pretorius, PM Deluca, GC Halliday, J Kerr, R Hofer, M |
| author_sort | Turnquist, C |
| collection | OXFORD |
| description | Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a rare central nervous system inflammatory disorder primarily affecting the brainstem and cerebellum. We report a case of CLIPPERS in a 45-year-old man presenting with left facial numbness and dizziness. Imaging studies were conducted repeatedly over an 8-year follow-up period. Given diagnostic uncertainty in the early stages of the disease, three serial biopsies were obtained, which together with the clinical and radiological findings, led to the diagnosis. This case highlights the diagnostic challenges regarding the rare entity of CLIPPERS and discusses the main differential diagnoses that are necessary to consider. Additionally, some of the atypical features of this case, including the presenting finding of a large, solidly enhancing lesion on radiological imaging and prominent plasma cells on pathology, contribute to expanding the spectrum of appearances for CLIPPERS. |
| first_indexed | 2024-03-06T20:22:05Z |
| format | Journal article |
| id | oxford-uuid:2e27fd08-5831-4643-b66b-e99994e5df45 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:22:05Z |
| publishDate | 2019 |
| publisher | Dustri-Verlag |
| record_format | dspace |
| spelling | oxford-uuid:2e27fd08-5831-4643-b66b-e99994e5df452022-03-26T12:47:19ZCLIPPERS: a case report with radiology, three serial biopsies and a literature reviewJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2e27fd08-5831-4643-b66b-e99994e5df45EnglishSymplectic Elements at OxfordDustri-Verlag2019Turnquist, CPretorius, PMDeluca, GCHalliday, JKerr, RHofer, MChronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a rare central nervous system inflammatory disorder primarily affecting the brainstem and cerebellum. We report a case of CLIPPERS in a 45-year-old man presenting with left facial numbness and dizziness. Imaging studies were conducted repeatedly over an 8-year follow-up period. Given diagnostic uncertainty in the early stages of the disease, three serial biopsies were obtained, which together with the clinical and radiological findings, led to the diagnosis. This case highlights the diagnostic challenges regarding the rare entity of CLIPPERS and discusses the main differential diagnoses that are necessary to consider. Additionally, some of the atypical features of this case, including the presenting finding of a large, solidly enhancing lesion on radiological imaging and prominent plasma cells on pathology, contribute to expanding the spectrum of appearances for CLIPPERS. |
| spellingShingle | Turnquist, C Pretorius, PM Deluca, GC Halliday, J Kerr, R Hofer, M CLIPPERS: a case report with radiology, three serial biopsies and a literature review |
| title | CLIPPERS: a case report with radiology, three serial biopsies and a literature review |
| title_full | CLIPPERS: a case report with radiology, three serial biopsies and a literature review |
| title_fullStr | CLIPPERS: a case report with radiology, three serial biopsies and a literature review |
| title_full_unstemmed | CLIPPERS: a case report with radiology, three serial biopsies and a literature review |
| title_short | CLIPPERS: a case report with radiology, three serial biopsies and a literature review |
| title_sort | clippers a case report with radiology three serial biopsies and a literature review |
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