Annexin 1: differential expression in tumor and mast cells in human larynx cancer.
Annexin 1 protein (ANXA1) expression was evaluated in tumor and mast cells in human larynx cancer and control epithelium. The effect of the exogenous ANXA1 (peptide Ac 2-26) was also examined during the cellular growth of the Hep-2 human larynx epidermoid carcinoma cell line. This peptide inhibited...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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| _version_ | 1826265345586888704 |
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| author | Silistino-Souza, R Rodrigues-Lisoni, F Cury, P Maniglia, J Raposo, L Tajara, E Christian, H Oliani, S |
| author_facet | Silistino-Souza, R Rodrigues-Lisoni, F Cury, P Maniglia, J Raposo, L Tajara, E Christian, H Oliani, S |
| author_sort | Silistino-Souza, R |
| collection | OXFORD |
| description | Annexin 1 protein (ANXA1) expression was evaluated in tumor and mast cells in human larynx cancer and control epithelium. The effect of the exogenous ANXA1 (peptide Ac 2-26) was also examined during the cellular growth of the Hep-2 human larynx epidermoid carcinoma cell line. This peptide inhibited the proliferation of the Hep-2 cells within 144 hr. In surgical tissue specimens from 20 patients with larynx cancer, ultrastructural immunocytochemistry analysis showed in vivo down-regulation of ANXA1 expression in the tumor and increased in mast cells and Hep-2 cells treated with peptide Ac2-26. Combined in vivo and in vitro analysis demonstrated that ANXA1 plays a regulatory role in laryngeal cancer cell growth. We believe that a better understanding of the regulatory mechanisms of ANXA1 in tumor and mast cells may lead to future biological targets for the therapeutic intervention of human larynx cancer. |
| first_indexed | 2024-03-06T20:22:14Z |
| format | Journal article |
| id | oxford-uuid:2e35679a-b6c9-4972-ab75-2fd84f1f1a39 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:22:14Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:2e35679a-b6c9-4972-ab75-2fd84f1f1a392022-03-26T12:47:38ZAnnexin 1: differential expression in tumor and mast cells in human larynx cancer.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2e35679a-b6c9-4972-ab75-2fd84f1f1a39EnglishSymplectic Elements at Oxford2007Silistino-Souza, RRodrigues-Lisoni, FCury, PManiglia, JRaposo, LTajara, EChristian, HOliani, SAnnexin 1 protein (ANXA1) expression was evaluated in tumor and mast cells in human larynx cancer and control epithelium. The effect of the exogenous ANXA1 (peptide Ac 2-26) was also examined during the cellular growth of the Hep-2 human larynx epidermoid carcinoma cell line. This peptide inhibited the proliferation of the Hep-2 cells within 144 hr. In surgical tissue specimens from 20 patients with larynx cancer, ultrastructural immunocytochemistry analysis showed in vivo down-regulation of ANXA1 expression in the tumor and increased in mast cells and Hep-2 cells treated with peptide Ac2-26. Combined in vivo and in vitro analysis demonstrated that ANXA1 plays a regulatory role in laryngeal cancer cell growth. We believe that a better understanding of the regulatory mechanisms of ANXA1 in tumor and mast cells may lead to future biological targets for the therapeutic intervention of human larynx cancer. |
| spellingShingle | Silistino-Souza, R Rodrigues-Lisoni, F Cury, P Maniglia, J Raposo, L Tajara, E Christian, H Oliani, S Annexin 1: differential expression in tumor and mast cells in human larynx cancer. |
| title | Annexin 1: differential expression in tumor and mast cells in human larynx cancer. |
| title_full | Annexin 1: differential expression in tumor and mast cells in human larynx cancer. |
| title_fullStr | Annexin 1: differential expression in tumor and mast cells in human larynx cancer. |
| title_full_unstemmed | Annexin 1: differential expression in tumor and mast cells in human larynx cancer. |
| title_short | Annexin 1: differential expression in tumor and mast cells in human larynx cancer. |
| title_sort | annexin 1 differential expression in tumor and mast cells in human larynx cancer |
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