Adiposity and NMR-measured lipid and metabolic biomarkers among 30,000 Mexican adults
<p><strong>Background:</strong> Adiposity is a major cause of morbidity and mortality in part due to effects on blood lipids. Nuclear magnetic resonance (NMR) spectroscopy provides direct information on >130 biomarkers mostly related to blood lipid particles.</p> <p>...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2022
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| _version_ | 1797108282234503168 |
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| author | Aguilar-Ramirez, D Herrington, WG Alegre-Díaz, J Staplin, N Ramírez-Reyes, R Gnatiuc, L Hill, M Romer, F Trichia, E Bragg, F Wade, R Lewington, S Collins, R Emberson, JR Kuri-Morales, P Tapia-Conyer, R |
| author_facet | Aguilar-Ramirez, D Herrington, WG Alegre-Díaz, J Staplin, N Ramírez-Reyes, R Gnatiuc, L Hill, M Romer, F Trichia, E Bragg, F Wade, R Lewington, S Collins, R Emberson, JR Kuri-Morales, P Tapia-Conyer, R |
| author_sort | Aguilar-Ramirez, D |
| collection | OXFORD |
| description | <p><strong>Background:</strong> Adiposity is a major cause of morbidity and mortality in part due to effects on blood lipids. Nuclear magnetic resonance (NMR) spectroscopy provides direct information on >130 biomarkers mostly related to blood lipid particles.</p>
<p><strong>Methods:</strong> Among 28,934 Mexican adults without chronic disease and not taking lipid-lowering therapy, we examine the cross-sectional relevance of body-mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), and hip circumference (HC) to NMR-measured metabolic biomarkers. Confounder-adjusted associations between each adiposity measure and NMR biomarkers are estimated before and after mutual adjustment for other adiposity measures.</p>
<p><strong>Results:</strong> Markers of general (ie, BMI), abdominal (ie, WC and WHR) and gluteo-femoral (ie, HC) adiposity all display similar and strong associations across the NMR-platform of biomarkers, particularly for biomarkers that increase cardiometabolic risk. Higher adiposity associates with higher levels of Apolipoprotein-B (about 0.35, 0.30, 0.35, and 0.25 SD higher Apolipoprotein-B per 2-SD higher BMI, WHR, WC, and HC, respectively), higher levels of very low-density lipoprotein particles (and the cholesterol, triglycerides, and phospholipids within these lipoproteins), higher levels of all fatty acids (particularly mono-unsaturated fatty acids) and multiple changes in other metabolic biomarkers including higher levels of branched-chain amino acids and the inflammation biomarker glycoprotein acetyls. Associations for general and abdominal adiposity are fairly independent of each other but, given general and abdominal adiposity, higher gluteo-femoral adiposity is associated with a strongly favourable cardiometabolic lipid profile.</p>
<p><strong>Conclusions:</strong> Our results provide insight to the lipidic and metabolomic signatures of different adiposity markers in a previously understudied population where adiposity is common but lipid-lowering therapy is not.</p> |
| first_indexed | 2024-03-07T07:27:00Z |
| format | Journal article |
| id | oxford-uuid:2e3c7e97-3e40-4914-a8a7-0333c2e56a57 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:27:00Z |
| publishDate | 2022 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:2e3c7e97-3e40-4914-a8a7-0333c2e56a572022-11-24T15:15:21ZAdiposity and NMR-measured lipid and metabolic biomarkers among 30,000 Mexican adultsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2e3c7e97-3e40-4914-a8a7-0333c2e56a57EnglishSymplectic ElementsSpringer Nature2022Aguilar-Ramirez, DHerrington, WGAlegre-Díaz, JStaplin, NRamírez-Reyes, RGnatiuc, LHill, MRomer, FTrichia, EBragg, FWade, RLewington, SCollins, REmberson, JRKuri-Morales, PTapia-Conyer, R<p><strong>Background:</strong> Adiposity is a major cause of morbidity and mortality in part due to effects on blood lipids. Nuclear magnetic resonance (NMR) spectroscopy provides direct information on >130 biomarkers mostly related to blood lipid particles.</p> <p><strong>Methods:</strong> Among 28,934 Mexican adults without chronic disease and not taking lipid-lowering therapy, we examine the cross-sectional relevance of body-mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), and hip circumference (HC) to NMR-measured metabolic biomarkers. Confounder-adjusted associations between each adiposity measure and NMR biomarkers are estimated before and after mutual adjustment for other adiposity measures.</p> <p><strong>Results:</strong> Markers of general (ie, BMI), abdominal (ie, WC and WHR) and gluteo-femoral (ie, HC) adiposity all display similar and strong associations across the NMR-platform of biomarkers, particularly for biomarkers that increase cardiometabolic risk. Higher adiposity associates with higher levels of Apolipoprotein-B (about 0.35, 0.30, 0.35, and 0.25 SD higher Apolipoprotein-B per 2-SD higher BMI, WHR, WC, and HC, respectively), higher levels of very low-density lipoprotein particles (and the cholesterol, triglycerides, and phospholipids within these lipoproteins), higher levels of all fatty acids (particularly mono-unsaturated fatty acids) and multiple changes in other metabolic biomarkers including higher levels of branched-chain amino acids and the inflammation biomarker glycoprotein acetyls. Associations for general and abdominal adiposity are fairly independent of each other but, given general and abdominal adiposity, higher gluteo-femoral adiposity is associated with a strongly favourable cardiometabolic lipid profile.</p> <p><strong>Conclusions:</strong> Our results provide insight to the lipidic and metabolomic signatures of different adiposity markers in a previously understudied population where adiposity is common but lipid-lowering therapy is not.</p> |
| spellingShingle | Aguilar-Ramirez, D Herrington, WG Alegre-Díaz, J Staplin, N Ramírez-Reyes, R Gnatiuc, L Hill, M Romer, F Trichia, E Bragg, F Wade, R Lewington, S Collins, R Emberson, JR Kuri-Morales, P Tapia-Conyer, R Adiposity and NMR-measured lipid and metabolic biomarkers among 30,000 Mexican adults |
| title | Adiposity and NMR-measured lipid and metabolic biomarkers among 30,000 Mexican adults |
| title_full | Adiposity and NMR-measured lipid and metabolic biomarkers among 30,000 Mexican adults |
| title_fullStr | Adiposity and NMR-measured lipid and metabolic biomarkers among 30,000 Mexican adults |
| title_full_unstemmed | Adiposity and NMR-measured lipid and metabolic biomarkers among 30,000 Mexican adults |
| title_short | Adiposity and NMR-measured lipid and metabolic biomarkers among 30,000 Mexican adults |
| title_sort | adiposity and nmr measured lipid and metabolic biomarkers among 30 000 mexican adults |
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