AChR deficiency due to epsilon-subunit mutations: two common mutations in the Netherlands.
Congenital myasthenic syndromes are a clinically and genetically heterogeneous group of hereditary disorders affecting neuromuscular transmission. We have identified mutations within the acetylcholine receptor (AChR) epsilon-subunit gene underlying congenital myasthenic syndromes in nine patients (s...
| Hauptverfasser: | , , , , , , , , , |
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| Format: | Journal article |
| Sprache: | English |
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2009
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| _version_ | 1826265357207207936 |
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| author | Faber, C Molenaar, P Vles, J Bonifati, D Verschuuren, J van Doorn, P Kuks, J Wokke, J Beeson, D De Baets, M |
| author_facet | Faber, C Molenaar, P Vles, J Bonifati, D Verschuuren, J van Doorn, P Kuks, J Wokke, J Beeson, D De Baets, M |
| author_sort | Faber, C |
| collection | OXFORD |
| description | Congenital myasthenic syndromes are a clinically and genetically heterogeneous group of hereditary disorders affecting neuromuscular transmission. We have identified mutations within the acetylcholine receptor (AChR) epsilon-subunit gene underlying congenital myasthenic syndromes in nine patients (seven kinships) of Dutch origin. Previously reported mutations epsilon1369delG and epsilonR311Q were found to be common; epsilon1369delG was present on at least one allele in seven of the nine patients, and epsilonR311Q in six. Phenotypes ranged from relatively mild ptosis and external ophthalmoplegia to generalized myasthenia. The common occurrence of epsilonR311Q and epsilon1369delG suggests a possible founder for each of these mutations originating in North Western Europe, possibly in Holland. Knowledge of the ethnic or geographic origin within Europe of AChR deficiency patients can help in targeting genetic screening and it may be possible to provide a rapid genetic diagnosis for patients of Dutch origin by screening first for epsilonR311Q and epsilon1369delG. |
| first_indexed | 2024-03-06T20:22:25Z |
| format | Journal article |
| id | oxford-uuid:2e46ac04-d270-4354-a88b-218f66180659 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:22:25Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:2e46ac04-d270-4354-a88b-218f661806592022-03-26T12:48:07ZAChR deficiency due to epsilon-subunit mutations: two common mutations in the Netherlands.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2e46ac04-d270-4354-a88b-218f66180659EnglishSymplectic Elements at Oxford2009Faber, CMolenaar, PVles, JBonifati, DVerschuuren, Jvan Doorn, PKuks, JWokke, JBeeson, DDe Baets, MCongenital myasthenic syndromes are a clinically and genetically heterogeneous group of hereditary disorders affecting neuromuscular transmission. We have identified mutations within the acetylcholine receptor (AChR) epsilon-subunit gene underlying congenital myasthenic syndromes in nine patients (seven kinships) of Dutch origin. Previously reported mutations epsilon1369delG and epsilonR311Q were found to be common; epsilon1369delG was present on at least one allele in seven of the nine patients, and epsilonR311Q in six. Phenotypes ranged from relatively mild ptosis and external ophthalmoplegia to generalized myasthenia. The common occurrence of epsilonR311Q and epsilon1369delG suggests a possible founder for each of these mutations originating in North Western Europe, possibly in Holland. Knowledge of the ethnic or geographic origin within Europe of AChR deficiency patients can help in targeting genetic screening and it may be possible to provide a rapid genetic diagnosis for patients of Dutch origin by screening first for epsilonR311Q and epsilon1369delG. |
| spellingShingle | Faber, C Molenaar, P Vles, J Bonifati, D Verschuuren, J van Doorn, P Kuks, J Wokke, J Beeson, D De Baets, M AChR deficiency due to epsilon-subunit mutations: two common mutations in the Netherlands. |
| title | AChR deficiency due to epsilon-subunit mutations: two common mutations in the Netherlands. |
| title_full | AChR deficiency due to epsilon-subunit mutations: two common mutations in the Netherlands. |
| title_fullStr | AChR deficiency due to epsilon-subunit mutations: two common mutations in the Netherlands. |
| title_full_unstemmed | AChR deficiency due to epsilon-subunit mutations: two common mutations in the Netherlands. |
| title_short | AChR deficiency due to epsilon-subunit mutations: two common mutations in the Netherlands. |
| title_sort | achr deficiency due to epsilon subunit mutations two common mutations in the netherlands |
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