Ultrasound contrast agent modeling: A review
Ultrasound is extensively used in medical imaging, being safe and inexpensive and operating in real time. Its scope of applications has been widely broadened by the use of ultrasound contrast agents (UCAs) in the form of microscopic bubbles coated by a biocompatible shell. Their increased use has mo...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2020
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| _version_ | 1826265392706748416 |
|---|---|
| author | Versluis, M Stride, E Lajoinie, G Dollet, B Segers, T |
| author_facet | Versluis, M Stride, E Lajoinie, G Dollet, B Segers, T |
| author_sort | Versluis, M |
| collection | OXFORD |
| description | Ultrasound is extensively used in medical imaging, being safe and inexpensive and operating in real
time. Its scope of applications has been widely broadened by the use of ultrasound contrast agents (UCAs) in the
form of microscopic bubbles coated by a biocompatible shell. Their increased use has motivated a large amount
of research to understand and characterize their physical properties as well as their interaction with the ultrasound field and their surrounding environment. Here we review the theoretical models that have been proposed
to study and predict the behavior of UCAs. We begin with a brief introduction on the development of UCAs. We
then present the basics of free-gas-bubble dynamics upon which UCA modeling is based. We review extensively
the linear and non-linear models for shell elasticity and viscosity and present models for non-spherical and asymmetric bubble oscillations, especially in the presence of surrounding walls or tissue. Then, higher-order effects
such as microstreaming, shedding and acoustic radiation forces are considered. We conclude this review with
promising directions for the modeling and development of novel agents. |
| first_indexed | 2024-03-06T20:22:59Z |
| format | Journal article |
| id | oxford-uuid:2e75ea38-46e4-4b4b-9e3f-093a76f16480 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:22:59Z |
| publishDate | 2020 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:2e75ea38-46e4-4b4b-9e3f-093a76f164802022-03-26T12:49:04ZUltrasound contrast agent modeling: A reviewJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2e75ea38-46e4-4b4b-9e3f-093a76f16480EnglishSymplectic ElementsElsevier2020Versluis, MStride, ELajoinie, GDollet, BSegers, TUltrasound is extensively used in medical imaging, being safe and inexpensive and operating in real time. Its scope of applications has been widely broadened by the use of ultrasound contrast agents (UCAs) in the form of microscopic bubbles coated by a biocompatible shell. Their increased use has motivated a large amount of research to understand and characterize their physical properties as well as their interaction with the ultrasound field and their surrounding environment. Here we review the theoretical models that have been proposed to study and predict the behavior of UCAs. We begin with a brief introduction on the development of UCAs. We then present the basics of free-gas-bubble dynamics upon which UCA modeling is based. We review extensively the linear and non-linear models for shell elasticity and viscosity and present models for non-spherical and asymmetric bubble oscillations, especially in the presence of surrounding walls or tissue. Then, higher-order effects such as microstreaming, shedding and acoustic radiation forces are considered. We conclude this review with promising directions for the modeling and development of novel agents. |
| spellingShingle | Versluis, M Stride, E Lajoinie, G Dollet, B Segers, T Ultrasound contrast agent modeling: A review |
| title | Ultrasound contrast agent modeling: A review |
| title_full | Ultrasound contrast agent modeling: A review |
| title_fullStr | Ultrasound contrast agent modeling: A review |
| title_full_unstemmed | Ultrasound contrast agent modeling: A review |
| title_short | Ultrasound contrast agent modeling: A review |
| title_sort | ultrasound contrast agent modeling a review |
| work_keys_str_mv | AT versluism ultrasoundcontrastagentmodelingareview AT stridee ultrasoundcontrastagentmodelingareview AT lajoinieg ultrasoundcontrastagentmodelingareview AT dolletb ultrasoundcontrastagentmodelingareview AT segerst ultrasoundcontrastagentmodelingareview |