Pharmacological targeting of IRE1 in cancer

Pharmacological targeting of IRE1 in cancer

IRE1α (inositol requiring enzyme 1 alpha) is one of the main transducers of the unfolded protein response (UPR). IRE1α plays instrumental protumoral roles in several cancers, and high IRE1α activity has been associated with poorer prognoses. In this context, IRE1α has been identified as a potentiall...

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Bibliographic Details
Main Authors:	Pelizzari Raymundo, D, Doultsinos, D, Guillory, X, Carlesso, A, Eriksson, LA, Chevet, E
Format:	Journal article
Language:	English
Published:	Cell Press 2020

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