Normal human immunoglobulin G4 is bispecific: it has two different antigen-combining sites.
Unlike other immunoglobulin G (IgG) subclasses, IgG4 antibodies in plasma have been reported to be functionally monovalent. In this paper we show that the apparent monovalency of circulating IgG4 is caused by asymmetry of plasma IgG4. A large fraction of plasma IgG4 molecules have two different anti...
Main Authors: | Schuurman, J, Van Ree, R, Perdok, G, Van Doorn, H, Tan, K, Aalberse, R |
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Format: | Journal article |
Language: | English |
Published: |
1999
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