Rare and low-frequency coding variants alter human adult height
Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1–4.8%) and effects of up to...
Main Authors: | Marouli, E, Graff, M, Medina-Gomez, M, Karaderi, T, Mahajan, A, Gan, W, Kitajima, H, Karpe, F, Morris, A, Neville, M, Owen, K, Robertson, N, Southam, L, McCarthy, M, Lindgren, C, al., E |
---|---|
Format: | Journal article |
Published: |
Nature Publishing Group
2017
|
Similar Items
-
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
by: Justice, A, et al.
Published: (2019) -
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
by: Mahajan, A, et al.
Published: (2018) -
A saturated map of common genetic variants associated with human height
by: Yengo, L, et al.
Published: (2022) -
A common variant of HMGA2 is associated with adult and childhood height in the general population.
by: Lindgren, C, et al.
Published: (2007) -
Relationship between common variants in the Stearoyl CoA desaturase (SCD) gene and intermediate phenotypes associated with type 2 diabetes
by: Jain, D, et al.
Published: (2005)