Annexin A1 in the brain--undiscovered roles?
Annexin A1 (ANXA1) is an endogenous protein known to have potent anti-inflammatory properties in the peripheral system. It has also been detected in the brain, but its function there is still ambiguous. In this review, we have, for the first time, collated the evidence currently available on the fun...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2008
|
| _version_ | 1797060919023370240 |
|---|---|
| author | Solito, E McArthur, S Christian, H Gavins, F Buckingham, J Gillies, G |
| author_facet | Solito, E McArthur, S Christian, H Gavins, F Buckingham, J Gillies, G |
| author_sort | Solito, E |
| collection | OXFORD |
| description | Annexin A1 (ANXA1) is an endogenous protein known to have potent anti-inflammatory properties in the peripheral system. It has also been detected in the brain, but its function there is still ambiguous. In this review, we have, for the first time, collated the evidence currently available on the function of ANXA1 in the brain and have proposed several possible mechanisms by which it exerts a neuroprotective or anti-neuroinflammatory function. We suggest that ANXA1, its small peptide mimetics and its receptors might be exciting new therapeutic targets in the management of a wide range of neuroinflammatory diseases, including stroke and neurodegenerative conditions. |
| first_indexed | 2024-03-06T20:23:41Z |
| format | Journal article |
| id | oxford-uuid:2eb07e33-a020-4a48-bb03-6f1ba669afdb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:23:41Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:2eb07e33-a020-4a48-bb03-6f1ba669afdb2022-03-26T12:50:25ZAnnexin A1 in the brain--undiscovered roles?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2eb07e33-a020-4a48-bb03-6f1ba669afdbEnglishSymplectic Elements at Oxford2008Solito, EMcArthur, SChristian, HGavins, FBuckingham, JGillies, GAnnexin A1 (ANXA1) is an endogenous protein known to have potent anti-inflammatory properties in the peripheral system. It has also been detected in the brain, but its function there is still ambiguous. In this review, we have, for the first time, collated the evidence currently available on the function of ANXA1 in the brain and have proposed several possible mechanisms by which it exerts a neuroprotective or anti-neuroinflammatory function. We suggest that ANXA1, its small peptide mimetics and its receptors might be exciting new therapeutic targets in the management of a wide range of neuroinflammatory diseases, including stroke and neurodegenerative conditions. |
| spellingShingle | Solito, E McArthur, S Christian, H Gavins, F Buckingham, J Gillies, G Annexin A1 in the brain--undiscovered roles? |
| title | Annexin A1 in the brain--undiscovered roles? |
| title_full | Annexin A1 in the brain--undiscovered roles? |
| title_fullStr | Annexin A1 in the brain--undiscovered roles? |
| title_full_unstemmed | Annexin A1 in the brain--undiscovered roles? |
| title_short | Annexin A1 in the brain--undiscovered roles? |
| title_sort | annexin a1 in the brain undiscovered roles |
| work_keys_str_mv | AT solitoe annexina1inthebrainundiscoveredroles AT mcarthurs annexina1inthebrainundiscoveredroles AT christianh annexina1inthebrainundiscoveredroles AT gavinsf annexina1inthebrainundiscoveredroles AT buckinghamj annexina1inthebrainundiscoveredroles AT gilliesg annexina1inthebrainundiscoveredroles |