People of the British Isles: Preliminary analysis of genotypes and surnames in a UK-control population
There is a great deal of interest in a fine-scale population structure in the UK, both as a signature of historical immigration events and because of the effect population structure may have on disease association studies. Although population structure appears to have a minor impact on the current g...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1797060930705555456 |
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| author | Winney, B Boumertit, A Day, T Davison, D Echeta, C Evseeva, I Hutnik, K Leslie, S Nicodemus, K Royrvik, E Tonks, S Yang, X Cheshire, J Longley, P Mateos, P Groom, A Relton, C Bishop, D Black, K Northwood, E Parkinson, L Frayling, T Steele, A Sampson, JR King, T |
| author_facet | Winney, B Boumertit, A Day, T Davison, D Echeta, C Evseeva, I Hutnik, K Leslie, S Nicodemus, K Royrvik, E Tonks, S Yang, X Cheshire, J Longley, P Mateos, P Groom, A Relton, C Bishop, D Black, K Northwood, E Parkinson, L Frayling, T Steele, A Sampson, JR King, T |
| author_sort | Winney, B |
| collection | OXFORD |
| description | There is a great deal of interest in a fine-scale population structure in the UK, both as a signature of historical immigration events and because of the effect population structure may have on disease association studies. Although population structure appears to have a minor impact on the current generation of genome-wide association studies, it is likely to have a significant part in the next generation of studies designed to search for rare variants. A powerful way of detecting such structure is to control and document carefully the provenance of the samples involved. In this study, we describe the collection of a cohort of rural UK samples (The People of the British Isles), aimed at providing a well-characterised UK-control population that can be used as a resource by the research community, as well as providing a fine-scale genetic information on the British population. So far, some 4000 samples have been collected, the majority of which fit the criteria of coming from a rural area and having all four grandparents from approximately the same area. Analysis of the first 3865 samples that have been geocoded indicates that 75% have a mean distance between grandparental places of birth of 37.3 km, and that about 70% of grandparental places of birth can be classed as rural. Preliminary genotyping of 1057 samples demonstrates the value of these samples for investigating a fine-scale population structure within the UK, and shows how this can be enhanced by the use of surnames. © 2012 Macmillan Publishers Limited All rights reserved. |
| first_indexed | 2024-03-06T20:23:51Z |
| format | Journal article |
| id | oxford-uuid:2ebc7268-ee81-46f0-87a7-53dfdbb40713 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:23:51Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:2ebc7268-ee81-46f0-87a7-53dfdbb407132022-03-26T12:50:51ZPeople of the British Isles: Preliminary analysis of genotypes and surnames in a UK-control populationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2ebc7268-ee81-46f0-87a7-53dfdbb40713EnglishSymplectic Elements at Oxford2012Winney, BBoumertit, ADay, TDavison, DEcheta, CEvseeva, IHutnik, KLeslie, SNicodemus, KRoyrvik, ETonks, SYang, XCheshire, JLongley, PMateos, PGroom, ARelton, CBishop, DBlack, KNorthwood, EParkinson, LFrayling, TSteele, ASampson, JRKing, TThere is a great deal of interest in a fine-scale population structure in the UK, both as a signature of historical immigration events and because of the effect population structure may have on disease association studies. Although population structure appears to have a minor impact on the current generation of genome-wide association studies, it is likely to have a significant part in the next generation of studies designed to search for rare variants. A powerful way of detecting such structure is to control and document carefully the provenance of the samples involved. In this study, we describe the collection of a cohort of rural UK samples (The People of the British Isles), aimed at providing a well-characterised UK-control population that can be used as a resource by the research community, as well as providing a fine-scale genetic information on the British population. So far, some 4000 samples have been collected, the majority of which fit the criteria of coming from a rural area and having all four grandparents from approximately the same area. Analysis of the first 3865 samples that have been geocoded indicates that 75% have a mean distance between grandparental places of birth of 37.3 km, and that about 70% of grandparental places of birth can be classed as rural. Preliminary genotyping of 1057 samples demonstrates the value of these samples for investigating a fine-scale population structure within the UK, and shows how this can be enhanced by the use of surnames. © 2012 Macmillan Publishers Limited All rights reserved. |
| spellingShingle | Winney, B Boumertit, A Day, T Davison, D Echeta, C Evseeva, I Hutnik, K Leslie, S Nicodemus, K Royrvik, E Tonks, S Yang, X Cheshire, J Longley, P Mateos, P Groom, A Relton, C Bishop, D Black, K Northwood, E Parkinson, L Frayling, T Steele, A Sampson, JR King, T People of the British Isles: Preliminary analysis of genotypes and surnames in a UK-control population |
| title | People of the British Isles: Preliminary analysis of genotypes and surnames in a UK-control population |
| title_full | People of the British Isles: Preliminary analysis of genotypes and surnames in a UK-control population |
| title_fullStr | People of the British Isles: Preliminary analysis of genotypes and surnames in a UK-control population |
| title_full_unstemmed | People of the British Isles: Preliminary analysis of genotypes and surnames in a UK-control population |
| title_short | People of the British Isles: Preliminary analysis of genotypes and surnames in a UK-control population |
| title_sort | people of the british isles preliminary analysis of genotypes and surnames in a uk control population |
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