Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function.

Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function.

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Crystallographic analysis of human Hfe has documented an overall structure similar to classical (class Ia) MHC molecules with a peptide binding groove deprived of ligand. Thus, to address the question of whether alphabeta T cells could recognize MHC molecules independently of bound ligands, we studi...

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Bibliographic Details
Main Authors: Rohrlich, P, Fazilleau, N, Ginhoux, F, Firat, H, Michel, F, Cochet, M, Laham, N, Roth, M, Pascolo, S, Nato, F, Coppin, H, Charneau, P, Danos, O, Acuto, O, Ehrlich, R, Kanellopoulos, J, Lemonnier, F
Format: Journal article
Language:English
Published: 2005

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