A quantitative comparison of wild-type and gatekeeper mutant Cdk2 for chemical genetic studies with ATP analogues

A quantitative comparison of wild-type and gatekeeper mutant Cdk2 for chemical genetic studies with ATP analogues

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Chemical genetic studies with enlarged ATP binding sites and unnatural ATP analogues have been applied to protein kinases for characterisation and substrate identification. Although this system is becoming widely used, there are limited data available about the kinetic profile of the modified system...

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Bibliographic Details
Main Authors:	Elphick, L, Lee, SE, Child, E, Prasad, A, Pignocchi, C, Thibaudeau, S, Anderson, A, Bonnac, L, Gouverneur, V, Mann, D
Format:	Journal article
Language:	English
Published:	2009

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