The farnesyltransferase inhibitor L744,832 reduces hypoxia in tumors expressing activated H-ras.

The farnesyltransferase inhibitor L744,832 reduces hypoxia in tumors expressing activated H-ras.

Many tumors contain extensive regions of hypoxia. Because hypoxic cells are markedly more resistant to killing by radiation, repeated attempts have been made to improve the oxygenation of tumors to enhance radiotherapy. We have studied the oxygenation of tumor xenografts in nude mice after treatment...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Cohen-Jonathan, E, Evans, S, Koch, C, Muschel, R, Mckenna, W, Wu, J, Bernhard, E
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2001

Eitemau Tebyg

Farnesyltransferase inhibitors as radiation sensitizers.
gan: Mckenna, W, et al.
Cyhoeddwyd: (2002)

K-Ras-Independent Effects of the Farnesyl Transferase Inhibitor L-744,832 on Cyclin B1/Cdc2 Kinase Activity, G2/M Cell Cycle Progression and Apoptosis in Human Pancreatic Ductal Adenocarcinoma Cell
gan: Si Young Song, et al.
Cyhoeddwyd: (2000-05-01)

Farnesyltransferase inhibitors as radiation sensitizers.
gan: Brunner, T, et al.
Cyhoeddwyd: (2003)

Farnesyltransferase inhibitors.
gan: Hahn, S, et al.
Cyhoeddwyd: (2001)

Farnesyltransferase inhibitors: an overview of the results of preclinical and clinical investigations.
gan: Brunner, T, et al.
Cyhoeddwyd: (2003)

Farnesyltransferase inhibitors as radiation sensitizers
gan: Mckenna, W
Cyhoeddwyd: (2005)

Farnesyltransferase inhibitors potentiate the antitumor effect of radiation on a human tumor xenograft expressing activated HRAS.
gan: Cohen-Jonathan, E, et al.
Cyhoeddwyd: (2000)

A Phase I trial of the farnesyltransferase inhibitor L-778,123 and radiotherapy for locally advanced lung and head and neck cancer.
gan: Hahn, S, et al.
Cyhoeddwyd: (2002)

Ras inhibitors and radiation therapy.
gan: Jones, H, et al.
Cyhoeddwyd: (2001)

A phase I trial of the dual farnesyltransferase and geranylgeranyltransferase inhibitor L-778,123 and radiotherapy for locally advanced pancreatic cancer.
gan: Martin, N, et al.
Cyhoeddwyd: (2004)

An overview on natural farnesyltransferase inhibitors for efficient cancer therapy
gan: Xiaohan Dai, et al.
Cyhoeddwyd: (2020-01-01)

Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice
gan: Leah K. Cuddy, et al.
Cyhoeddwyd: (2022-08-01)

Ras regulation of radioresistance in cell culture.
gan: Gupta, A, et al.
Cyhoeddwyd: (2001)

Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria
gan: Shao H. Yang, et al.
Cyhoeddwyd: (2010-02-01)

Bioactivity of Farnesyltransferase Inhibitors Against Entamoeba histolytica and Schistosoma mansoni
gan: Alexandra Probst, et al.
Cyhoeddwyd: (2019-05-01)

The RAS signal transduction pathway and its role in radiation sensitivity.
gan: Mckenna, W, et al.
Cyhoeddwyd: (2003)

Ras, metastasis, and matrix metalloproteinase 9.
gan: Bernhard, E, et al.
Cyhoeddwyd: (2001)

Modifying radiosensitivity in tumors: Targeting the Ras-PI-3 kinase pathway.
gan: Muschel, R, et al.
Cyhoeddwyd: (2001)

The Ras radiation resistance pathway.
gan: Gupta, A, et al.
Cyhoeddwyd: (2001)

DNA as an important target in radiation-induced apoptosis of MYC and MYC plus RAS transfected rat embryo fibroblasts.
gan: Ayene, I, et al.
Cyhoeddwyd: (2000)

A phase I trial of the farnesyltransferase and geranylgeranyltransferase-I inhibitor L-778,123 (L-778) and radiotherapy for locally advanced pancreatic cancer.
gan: Martin, N, et al.
Cyhoeddwyd: (2004)

Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase.
gan: Van Voorhis, W, et al.
Cyhoeddwyd: (2007)

Phenothiazine- and Carbazole-Cyanochalcones as Dual Inhibitors of Tubulin Polymerization and Human Farnesyltransferase
gan: Andreea Zubaș, et al.
Cyhoeddwyd: (2023-06-01)

Inhibition of oncogene-induced inflammatory chemokines using a farnesyltransferase inhibitor
gan: Rothstein Jay L, et al.
Cyhoeddwyd: (2008-02-01)

Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase.
gan: Hast, M, et al.
Cyhoeddwyd: (2009)

Farnesyltransferase-inhibitors exert in vitro immunosuppressive capacity by inhibiting human B-cells
gan: Shilei Xu, et al.
Cyhoeddwyd: (2023-11-01)

The use of signal transduction inhibitors with radiation
gan: Mckenna, W, et al.
Cyhoeddwyd: (2006)

Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines.
gan: Bernhard, E, et al.
Cyhoeddwyd: (2000)

Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104)
gan: Gajewski Thomas F, et al.
Cyhoeddwyd: (2012-12-01)

Virtual Lead Identification of Farnesyltransferase Inhibitors Based on Ligand and Structure-Based Pharmacophore Techniques
gan: Nizar M. Mhaidat, et al.
Cyhoeddwyd: (2013-05-01)

Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents.
gan: Fletcher, S, et al.
Cyhoeddwyd: (2010)

Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells
gan: Husheng Ding, et al.
Cyhoeddwyd: (2014-01-01)

C-Raf-1 protein kinase is not essential for Ras transformation of mouse embryo fibroblasts.
gan: Gupta, A, et al.
Cyhoeddwyd: (2003)

RAS-Mediated radiation resistance is not linked to MAP kinase activation in two bladder carcinoma cell lines.
gan: Gupta, A, et al.
Cyhoeddwyd: (2000)

CCNP TSHOOT 642-832 : quick reference /
gan: Stewart, Brent, author
Cyhoeddwyd: (2010)

Exploring Protoheme IX Farnesyltransferase as an Antimalarial Drug Target
gan: Edelen, Samantha Leigh
Cyhoeddwyd: (2022)

Analyzing the postulated inhibitory effect of Manumycin A on farnesyltransferase
gan: Anna Hagemann, et al.
Cyhoeddwyd: (2022-12-01)

Radiation sensitization by inhibition of activated Ras.
gan: Brunner, T, et al.
Cyhoeddwyd: (2004)

Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein
gan: Qi Yang, et al.
Cyhoeddwyd: (2024-06-01)

Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments
gan: Nguyen Thi Ha, et al.
Cyhoeddwyd: (2020-10-01)