Spatio-temporal dynamics of cortical drive to human subthalamic nucleus neurons in Parkinson's disease
Pathological synchronisation of beta frequency (12-35Hz) oscillations between the subthalamic nucleus (STN) and cerebral cortex is thought to contribute to motor impairment in Parkinson's disease (PD). For this cortico-subthalamic oscillatory drive to be mechanistically important, it must influ...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2018
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| _version_ | 1797061019549302784 |
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| author | Sharott, A Gulberti, A Hamel, W Köppen, J Münchau, A Buhmann, C Pötter-Nerger, M Westphal, M Gerloff, C Moll, C Engel, A |
| author_facet | Sharott, A Gulberti, A Hamel, W Köppen, J Münchau, A Buhmann, C Pötter-Nerger, M Westphal, M Gerloff, C Moll, C Engel, A |
| author_sort | Sharott, A |
| collection | OXFORD |
| description | Pathological synchronisation of beta frequency (12-35Hz) oscillations between the subthalamic nucleus (STN) and cerebral cortex is thought to contribute to motor impairment in Parkinson's disease (PD). For this cortico-subthalamic oscillatory drive to be mechanistically important, it must influence the firing of STN neurons and, consequently, their downstream targets. Here, we examined the dynamics of synchronisation between STN LFPs and units with multiple cortical areas, measured using frontal ECoG, midline EEG and lateral EEG, during rest and movement. STN neurons lagged cortical signals recorded over midline (over premotor cortices) and frontal (over prefrontal cortices) with stable time delays, consistent with strong corticosubthalamic drive, and many neurons maintained these dynamics during movement. In contrast, most STN neurons desynchronised from lateral EEG signals (over primary motor cortices) during movement and those that did not had altered phase relations to the cortical signals. The strength of synchronisation between STN units and midline EEG in the high beta range (25-35Hz) correlated positively with the severity of akinetic-rigid motor symptoms across patients. Together, these results suggest that sustained synchronisation of STN neurons to premotor-cortical beta oscillations play an important role in disrupting the normal coding of movement in PD. |
| first_indexed | 2024-03-06T20:25:07Z |
| format | Journal article |
| id | oxford-uuid:2f22d042-289a-4bf6-b6fd-b9a69f000df9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:25:07Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:2f22d042-289a-4bf6-b6fd-b9a69f000df92022-03-26T12:53:25ZSpatio-temporal dynamics of cortical drive to human subthalamic nucleus neurons in Parkinson's diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2f22d042-289a-4bf6-b6fd-b9a69f000df9EnglishSymplectic Elements at OxfordElsevier2018Sharott, AGulberti, AHamel, WKöppen, JMünchau, ABuhmann, CPötter-Nerger, MWestphal, MGerloff, CMoll, CEngel, APathological synchronisation of beta frequency (12-35Hz) oscillations between the subthalamic nucleus (STN) and cerebral cortex is thought to contribute to motor impairment in Parkinson's disease (PD). For this cortico-subthalamic oscillatory drive to be mechanistically important, it must influence the firing of STN neurons and, consequently, their downstream targets. Here, we examined the dynamics of synchronisation between STN LFPs and units with multiple cortical areas, measured using frontal ECoG, midline EEG and lateral EEG, during rest and movement. STN neurons lagged cortical signals recorded over midline (over premotor cortices) and frontal (over prefrontal cortices) with stable time delays, consistent with strong corticosubthalamic drive, and many neurons maintained these dynamics during movement. In contrast, most STN neurons desynchronised from lateral EEG signals (over primary motor cortices) during movement and those that did not had altered phase relations to the cortical signals. The strength of synchronisation between STN units and midline EEG in the high beta range (25-35Hz) correlated positively with the severity of akinetic-rigid motor symptoms across patients. Together, these results suggest that sustained synchronisation of STN neurons to premotor-cortical beta oscillations play an important role in disrupting the normal coding of movement in PD. |
| spellingShingle | Sharott, A Gulberti, A Hamel, W Köppen, J Münchau, A Buhmann, C Pötter-Nerger, M Westphal, M Gerloff, C Moll, C Engel, A Spatio-temporal dynamics of cortical drive to human subthalamic nucleus neurons in Parkinson's disease |
| title | Spatio-temporal dynamics of cortical drive to human subthalamic nucleus neurons in Parkinson's disease |
| title_full | Spatio-temporal dynamics of cortical drive to human subthalamic nucleus neurons in Parkinson's disease |
| title_fullStr | Spatio-temporal dynamics of cortical drive to human subthalamic nucleus neurons in Parkinson's disease |
| title_full_unstemmed | Spatio-temporal dynamics of cortical drive to human subthalamic nucleus neurons in Parkinson's disease |
| title_short | Spatio-temporal dynamics of cortical drive to human subthalamic nucleus neurons in Parkinson's disease |
| title_sort | spatio temporal dynamics of cortical drive to human subthalamic nucleus neurons in parkinson s disease |
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