Integrative GWAS and co-localisation analysis suggests novel genes associated with age-related multimorbidity

Integrative GWAS and co-localisation analysis suggests novel genes associated with age-related multimorbidity

Advancing age is the greatest risk factor for developing multiple age-related diseases. Therapeutic approaches targeting the underlying pathways of ageing, rather than individual diseases, may be an effective way to treat and prevent age-related morbidity while reducing the burden of polypharmacy. W...

Full description

Bibliographic Details
Main Authors:	West, CE, Karim, M, Falaguera, MJ, Speidel, L, Green, CJ, Logie, L, Schwartzentruber, J, Ochoa, D, Lord, JM, Ferguson, MAJ, Bountra, C, Wilkinson, GF, Vaughan, B, Leach, AR, Dunham, I, Marsden, BD
Format:	Journal article
Language:	English
Published:	Springer Nature 2023

Similar Items

Integrative GWAS and co-localisation analysis suggests novel genes associated with age-related multimorbidity
by: Clare E. West, et al.
Published: (2023-09-01)

GWAS.
by: Flint, J
Published: (2013)

Application of GWAS and mGWAS in Livestock and Poultry Breeding
by: Jing Ren, et al.
Published: (2024-08-01)

Problems in interpreting and using GWAS of conditional phenotypes illustrated by 'alcohol GWAS'
by: Holmes, M, et al.
Published: (2018)

bioGWAS: A Simple and Flexible Tool for Simulating GWAS Datasets
by: Anton I. Changalidis, et al.
Published: (2023-12-01)

The influence of multimorbidity on the management of patients with hip osteoarthritis
by: Ferguson, R
Published: (2021)

Spatial localisation and sensing in two dimensions via metasurfaces
by: Dima, G, et al.
Published: (2024)

pandasGWAS: a Python package for easy retrieval of GWAS catalog data
by: Tianze Cao, et al.
Published: (2023-05-01)

Deriving GWAS summary estimates for paternal smoking in UK biobank: a GWAS by subtraction
by: Benjamin Woolf, et al.
Published: (2023-07-01)

Identification and Functional Annotation of Genes Related to Horses’ Performance: From GWAS to Post-GWAS
by: Thayssa O. Littiere, et al.
Published: (2020-07-01)

Five years of GWAS discovery
by: Visscher, P, et al.
Published: (2012)

Five years of GWAS discovery.
by: Visscher, P, et al.
Published: (2012)

Hernia GWAS summary statistics
by: Wiberg, A, et al.
Published: (2022)

GWAS on retinal vasculometry phenotypes
by: Xiaofan Jiang, et al.
Published: (2023-02-01)

GWAS in the southern African context.
by: Yolandi Swart, et al.
Published: (2022-01-01)

GWAS on retinal vasculometry phenotypes.
by: Xiaofan Jiang, et al.
Published: (2023-02-01)

Correction: Deriving GWAS summary estimates for paternal smoking in UK biobank: a GWAS by subtraction
by: Benjamin Woolf, et al.
Published: (2025-02-01)

Heritability and family-based GWAS analyses of the N-acyl ethanolamine and ceramide plasma lipidome
by: McGurk, KA, et al.
Published: (2021)

Mechanisms and roles of mitochondrial localisation and dynamics in neuronal function
by: Lee, L, et al.
Published: (2020)

GWAS Explorer: an open-source tool to explore, visualize, and access GWAS summary statistics in the PLCO Atlas
by: Mitchell J. Machiela, et al.
Published: (2023-01-01)

Multimorbidity and complex multimorbidity in Brazilians with severe obesity
by: Ana Paula dos Santos Rodrigues, et al.
Published: (2023-10-01)

Handedness GWAS summary statistic files
by: Wiberg, A
Published: (2019)

Dissecting heterogeneity in GWAS meta-analysis
by: Magosi, L
Published: (2017)

Varicose veins GWAS summary statistics
by: Wiberg, A, et al.
Published: (2022)

Stability of bivariate GWAS biomarker detection.
by: Justin Bedő, et al.
Published: (2014-01-01)

Post-GWAS era in genetics of schizophrenia
by: V. E. Golimbet, et al.
Published: (2019-12-01)

GWAS for the composite traits of hematuria and albuminuria
by: Sarah A. Gagliano Taliun, et al.
Published: (2023-10-01)

Bench Research Informed by GWAS Results
by: Nikolay V. Kondratyev, et al.
Published: (2021-11-01)

10 Years of GWAS in intraocular pressure
by: Xiaoyi Raymond Gao, et al.
Published: (2023-04-01)

Postgwas: advanced GWAS interpretation in R.
by: Milan Hiersche, et al.
Published: (2013-01-01)

Iris localisation /
by: Lee, Hock Siong, 1988- author, et al.
Published: (2012)

Iris localisation /
by: Lee, Hock Siong, 1988- author, et al.
Published: (2012)

Localisation of ecto-5'-nucleotidase in mouse kidney using immunoelectron microscopy
by: Ferguson, D, et al.
Published: (1994)

Cytosine arabinoside affects the heat and capsaicin receptor TRPV1 localisation and sensitivity in human sensory neurons.
by: Anand, U, et al.
Published: (2008)

GWAS, MWAS and mGWAS provide insights into precision agriculture based on genotype-dependent microbial effects in foxtail millet
by: Yayu Wang, et al.
Published: (2022-10-01)

Single-Step GBLUP and GWAS Analyses Suggests Implementation of Unweighted Two Trait Approach for Heat Stress in Swine
by: Gabriella Roby Dodd, et al.
Published: (2022-02-01)

GWAS and functional studies suggest a role for altered DNA repair in the evolution of drug resistance in Mycobacterium tuberculosis
by: Saba Naz, et al.
Published: (2023-01-01)

Sustainable energy opportunities in localised food production and transportation: A case study of bread in the UK
by: López-Avilés, A, et al.
Published: (2019)

Quantifying Missing Heritability at Known GWAS Loci
by: Gusev, Alexander, et al.
Published: (2014)

The utility of mouse models in post-GWAS research
by: Lewis, A, et al.
Published: (2012)