Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

T cell receptor (TCR) activation and signaling precede immunological synapse formation and are sustained for hours after initiation. However, the precise physical sites of the initial and sustained TCR signaling are not definitively known. We report here that T cell activation was initiated and sust...

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Bibliographic Details
Main Authors:	Yokosuka, T, Sakata-Sogawa, K, Kobayashi, W, Hiroshima, M, Hashimoto-Tane, A, Tokunaga, M, Dustin, M, Saito, T
Format:	Journal article
Language:	English
Published:	2005

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