The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase.

The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase.

Post-translational modification of proteins by poly(ADP-ribosyl)ation regulates many cellular pathways that are critical for genome stability, including DNA repair, chromatin structure, mitosis and apoptosis. Poly(ADP-ribose) (PAR) is composed of repeating ADP-ribose units linked via a unique glycos...

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Bibliographic Details
Main Authors:	Slade, D, Dunstan, MS, Barkauskaite, E, Weston, R, Lafite, P, Dixon, N, Ahel, M, Leys, D, Ahel, I
Format:	Journal article
Language:	English
Published:	2011

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