A common haplotype of the TNF receptor 2 gene modulates endotoxin tolerance.

Endotoxin tolerance is characterized by the suppression of further TNF release upon recurrent exposure to LPS. This phenomenon is proposed to act as a homeostatic mechanism preventing uncontrolled cytokine release such as that observed in bacterial sepsis. The regulatory mechanisms and interindividu...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän: Fairfax, B, Davenport, E, Makino, S, Hill, A, Vannberg, F, Knight, J
Materialtyp: Journal article
Språk:English
Publicerad: 2011

Liknande verk