Estimation of the motor threshold for near-rectangular stimuli using the Hodgkin–Huxley model
The motor threshold measurement is a standard in preintervention probing in TMS experiments. We aim to predict the motor threshold for near-rectangular stimuli to efficiently determine the motor threshold size before any experiments take place. Estimating the behavior of large-scale networks require...
| Autors principals: | , , , |
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| Format: | Journal article |
| Idioma: | English |
| Publicat: |
Hindawi
2021
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| _version_ | 1826265571936698368 |
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| author | Memarian Sorkhabi, M Wendt, K Wilson, MT Denison, T |
| author_facet | Memarian Sorkhabi, M Wendt, K Wilson, MT Denison, T |
| author_sort | Memarian Sorkhabi, M |
| collection | OXFORD |
| description | The motor threshold measurement is a standard in preintervention probing in TMS experiments. We aim to predict the motor threshold for near-rectangular stimuli to efficiently determine the motor threshold size before any experiments take place. Estimating the behavior of large-scale networks requires dynamically accurate and efficient modeling. We utilized a Hodgkin–Huxley (HH) type model to evaluate motor threshold values and computationally validated its function with known true threshold data from 50 participants trials from state-of-the-art published datasets. For monophasic, bidirectional, and unidirectional rectangular stimuli in posterior-anterior or anterior-posterior directions as generated by the cTMS device, computational modeling of the HH model captured the experimentally measured population-averaged motor threshold values at high precision (maximum error ≤ 8%). The convergence of our biophysically based modeling study with experimental data in humans reveals that the effect of the stimulus shape is strongly correlated with the activation kinetics of the voltage-gated ion channels. The proposed method can reliably predict motor threshold size using the conductance-based neuronal models and could therefore be embedded in new generation neurostimulators. Advancements in neural modeling will make it possible to enhance treatment procedures by reducing the number of delivered magnetic stimuli to participants.
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| first_indexed | 2024-03-06T20:25:47Z |
| format | Journal article |
| id | oxford-uuid:2f5a741f-a5fb-4258-91a8-6a31fdadc5f9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:25:47Z |
| publishDate | 2021 |
| publisher | Hindawi |
| record_format | dspace |
| spelling | oxford-uuid:2f5a741f-a5fb-4258-91a8-6a31fdadc5f92022-03-26T12:54:51ZEstimation of the motor threshold for near-rectangular stimuli using the Hodgkin–Huxley modelJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2f5a741f-a5fb-4258-91a8-6a31fdadc5f9EnglishSymplectic ElementsHindawi2021Memarian Sorkhabi, MWendt, KWilson, MTDenison, TThe motor threshold measurement is a standard in preintervention probing in TMS experiments. We aim to predict the motor threshold for near-rectangular stimuli to efficiently determine the motor threshold size before any experiments take place. Estimating the behavior of large-scale networks requires dynamically accurate and efficient modeling. We utilized a Hodgkin–Huxley (HH) type model to evaluate motor threshold values and computationally validated its function with known true threshold data from 50 participants trials from state-of-the-art published datasets. For monophasic, bidirectional, and unidirectional rectangular stimuli in posterior-anterior or anterior-posterior directions as generated by the cTMS device, computational modeling of the HH model captured the experimentally measured population-averaged motor threshold values at high precision (maximum error ≤ 8%). The convergence of our biophysically based modeling study with experimental data in humans reveals that the effect of the stimulus shape is strongly correlated with the activation kinetics of the voltage-gated ion channels. The proposed method can reliably predict motor threshold size using the conductance-based neuronal models and could therefore be embedded in new generation neurostimulators. Advancements in neural modeling will make it possible to enhance treatment procedures by reducing the number of delivered magnetic stimuli to participants. |
| spellingShingle | Memarian Sorkhabi, M Wendt, K Wilson, MT Denison, T Estimation of the motor threshold for near-rectangular stimuli using the Hodgkin–Huxley model |
| title | Estimation of the motor threshold for near-rectangular stimuli using the Hodgkin–Huxley model |
| title_full | Estimation of the motor threshold for near-rectangular stimuli using the Hodgkin–Huxley model |
| title_fullStr | Estimation of the motor threshold for near-rectangular stimuli using the Hodgkin–Huxley model |
| title_full_unstemmed | Estimation of the motor threshold for near-rectangular stimuli using the Hodgkin–Huxley model |
| title_short | Estimation of the motor threshold for near-rectangular stimuli using the Hodgkin–Huxley model |
| title_sort | estimation of the motor threshold for near rectangular stimuli using the hodgkin huxley model |
| work_keys_str_mv | AT memariansorkhabim estimationofthemotorthresholdfornearrectangularstimuliusingthehodgkinhuxleymodel AT wendtk estimationofthemotorthresholdfornearrectangularstimuliusingthehodgkinhuxleymodel AT wilsonmt estimationofthemotorthresholdfornearrectangularstimuliusingthehodgkinhuxleymodel AT denisont estimationofthemotorthresholdfornearrectangularstimuliusingthehodgkinhuxleymodel |