Effects of different levels of end-tidal PO2 on ventilation during isocapnia in humans.

The purpose of this investigation was to examine how the ventilatory decline observed during sustained, eucapnic hypoxia (HVD) is affected by different levels of hypoxia. Six subjects were each studied 3-6 times at each of 5 different levels of isocapnic hypoxia (end-tidal PO2 equal to 45, 50, 55, 6...

Full description

Bibliographic Details
Main Authors: Bascom, D, Pandit, J, Clement, I, Robbins, P
Format: Journal article
Language:English
Published: 1992
_version_ 1826265631949848576
author Bascom, D
Pandit, J
Clement, I
Robbins, P
author_facet Bascom, D
Pandit, J
Clement, I
Robbins, P
author_sort Bascom, D
collection OXFORD
description The purpose of this investigation was to examine how the ventilatory decline observed during sustained, eucapnic hypoxia (HVD) is affected by different levels of hypoxia. Six subjects were each studied 3-6 times at each of 5 different levels of isocapnic hypoxia (end-tidal PO2 equal to 45, 50, 55, 65 and 75 Torr) in random order. The following variables were linearly related to saturation: (1) the rapid increase in ventilation at the onset of hypoxia; (2) the decline in ventilation over the period of hypoxia; and (3) the undershoot in ventilation below the pre-hypoxic control values at the relief of hypoxia. The rapid decrease in ventilation at the relief of hypoxia, however, was not linearly related to saturation. The mean time to peak ventilation was 2.13 +/- 0.07 min (+/- SE) at the onset of hypoxia, which was significantly longer (P less than 0.05) than the time to minimum ventilation at the relief of hypoxia of 1.23 +/- 0.18 min. The recovery from the undershoot in ventilation was 95% +/- 3% complete after 5 min, whereas the recovery in sensitivity to hypoxia was only 35% +/- 13% complete after 5 min of euoxia.
first_indexed 2024-03-06T20:26:42Z
format Journal article
id oxford-uuid:2fa3fb29-48f7-4ba7-9a40-e26528407e5c
institution University of Oxford
language English
last_indexed 2024-03-06T20:26:42Z
publishDate 1992
record_format dspace
spelling oxford-uuid:2fa3fb29-48f7-4ba7-9a40-e26528407e5c2022-03-26T12:56:33ZEffects of different levels of end-tidal PO2 on ventilation during isocapnia in humans.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2fa3fb29-48f7-4ba7-9a40-e26528407e5cEnglishSymplectic Elements at Oxford1992Bascom, DPandit, JClement, IRobbins, PThe purpose of this investigation was to examine how the ventilatory decline observed during sustained, eucapnic hypoxia (HVD) is affected by different levels of hypoxia. Six subjects were each studied 3-6 times at each of 5 different levels of isocapnic hypoxia (end-tidal PO2 equal to 45, 50, 55, 65 and 75 Torr) in random order. The following variables were linearly related to saturation: (1) the rapid increase in ventilation at the onset of hypoxia; (2) the decline in ventilation over the period of hypoxia; and (3) the undershoot in ventilation below the pre-hypoxic control values at the relief of hypoxia. The rapid decrease in ventilation at the relief of hypoxia, however, was not linearly related to saturation. The mean time to peak ventilation was 2.13 +/- 0.07 min (+/- SE) at the onset of hypoxia, which was significantly longer (P less than 0.05) than the time to minimum ventilation at the relief of hypoxia of 1.23 +/- 0.18 min. The recovery from the undershoot in ventilation was 95% +/- 3% complete after 5 min, whereas the recovery in sensitivity to hypoxia was only 35% +/- 13% complete after 5 min of euoxia.
spellingShingle Bascom, D
Pandit, J
Clement, I
Robbins, P
Effects of different levels of end-tidal PO2 on ventilation during isocapnia in humans.
title Effects of different levels of end-tidal PO2 on ventilation during isocapnia in humans.
title_full Effects of different levels of end-tidal PO2 on ventilation during isocapnia in humans.
title_fullStr Effects of different levels of end-tidal PO2 on ventilation during isocapnia in humans.
title_full_unstemmed Effects of different levels of end-tidal PO2 on ventilation during isocapnia in humans.
title_short Effects of different levels of end-tidal PO2 on ventilation during isocapnia in humans.
title_sort effects of different levels of end tidal po2 on ventilation during isocapnia in humans
work_keys_str_mv AT bascomd effectsofdifferentlevelsofendtidalpo2onventilationduringisocapniainhumans
AT panditj effectsofdifferentlevelsofendtidalpo2onventilationduringisocapniainhumans
AT clementi effectsofdifferentlevelsofendtidalpo2onventilationduringisocapniainhumans
AT robbinsp effectsofdifferentlevelsofendtidalpo2onventilationduringisocapniainhumans