The effects of a met-enkephalin analogue on ACTH, beta-LPH, beta-endorphin and MET-enkephalin in patients with adrenocortical disease.
Thirteen patients with either Addison's disease, or Cushing's disease treated by bilateral adrenalectomy, were infused with the long-acting met-enkephalin analogue DAMME. In patients with Addison's disease significant and pronounced falls in ACTH and N- and C-terminal beta-LPH were se...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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1981
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| _version_ | 1826265640721186816 |
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| author | Gaillard, R Grossman, A Smith, R Rees, L Besser, G |
| author_facet | Gaillard, R Grossman, A Smith, R Rees, L Besser, G |
| author_sort | Gaillard, R |
| collection | OXFORD |
| description | Thirteen patients with either Addison's disease, or Cushing's disease treated by bilateral adrenalectomy, were infused with the long-acting met-enkephalin analogue DAMME. In patients with Addison's disease significant and pronounced falls in ACTH and N- and C-terminal beta-LPH were seen; chromatography suggested that beta-endorphin fell concomitantly. Three out of four patients with Cushing's disease who had not received pituitary irradiation, also showed a decrease in plasma ACTH and N- and C-terminal beta-LPH; however, no change was seen in any of the irradiated patients. The changes were naloxone reversible. The levels of plasma met-enkephalin were normal and did not change after DAMME in any group of patients. These results are interpreted as suggesting that there are inhibitory opiate receptors controlling the release of ACTH, beta-LPH, and beta-endorphin. |
| first_indexed | 2024-03-06T20:26:50Z |
| format | Journal article |
| id | oxford-uuid:2faf504a-ddd9-4af1-9ccb-cb93e8db0b92 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:26:50Z |
| publishDate | 1981 |
| record_format | dspace |
| spelling | oxford-uuid:2faf504a-ddd9-4af1-9ccb-cb93e8db0b922022-03-26T12:56:48ZThe effects of a met-enkephalin analogue on ACTH, beta-LPH, beta-endorphin and MET-enkephalin in patients with adrenocortical disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2faf504a-ddd9-4af1-9ccb-cb93e8db0b92EnglishSymplectic Elements at Oxford1981Gaillard, RGrossman, ASmith, RRees, LBesser, GThirteen patients with either Addison's disease, or Cushing's disease treated by bilateral adrenalectomy, were infused with the long-acting met-enkephalin analogue DAMME. In patients with Addison's disease significant and pronounced falls in ACTH and N- and C-terminal beta-LPH were seen; chromatography suggested that beta-endorphin fell concomitantly. Three out of four patients with Cushing's disease who had not received pituitary irradiation, also showed a decrease in plasma ACTH and N- and C-terminal beta-LPH; however, no change was seen in any of the irradiated patients. The changes were naloxone reversible. The levels of plasma met-enkephalin were normal and did not change after DAMME in any group of patients. These results are interpreted as suggesting that there are inhibitory opiate receptors controlling the release of ACTH, beta-LPH, and beta-endorphin. |
| spellingShingle | Gaillard, R Grossman, A Smith, R Rees, L Besser, G The effects of a met-enkephalin analogue on ACTH, beta-LPH, beta-endorphin and MET-enkephalin in patients with adrenocortical disease. |
| title | The effects of a met-enkephalin analogue on ACTH, beta-LPH, beta-endorphin and MET-enkephalin in patients with adrenocortical disease. |
| title_full | The effects of a met-enkephalin analogue on ACTH, beta-LPH, beta-endorphin and MET-enkephalin in patients with adrenocortical disease. |
| title_fullStr | The effects of a met-enkephalin analogue on ACTH, beta-LPH, beta-endorphin and MET-enkephalin in patients with adrenocortical disease. |
| title_full_unstemmed | The effects of a met-enkephalin analogue on ACTH, beta-LPH, beta-endorphin and MET-enkephalin in patients with adrenocortical disease. |
| title_short | The effects of a met-enkephalin analogue on ACTH, beta-LPH, beta-endorphin and MET-enkephalin in patients with adrenocortical disease. |
| title_sort | effects of a met enkephalin analogue on acth beta lph beta endorphin and met enkephalin in patients with adrenocortical disease |
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