Characterization of the SARS-CoV-2 ExoN (nsp14ExoN–nsp10) complex: implications for its role in viral genome stability and inhibitor identification

Characterization of the SARS-CoV-2 ExoN (nsp14ExoN–nsp10) complex: implications for its role in viral genome stability and inhibitor identification

The SARS-CoV-2 coronavirus is the causal agent of the current global pandemic. SARS-CoV-2 belongs to an order, Nidovirales, with very large RNA genomes. It is proposed that the fidelity of coronavirus (CoV) genome replication is aided by an RNA nuclease complex, comprising the non-structural protein...

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Bibliographic Details
Main Authors: Baddock, HT, Brolih, S, Yosaatmadja, Y, Ratnaweera, M, Bielinski, M, Swift, LP, Cruz-Migoni, A, Fan, H, Keown, JR, Walker, AP, Morris, GM, Grimes, JM, Fodor, E, Schofield, CJ, Gileadi, O, McHugh, PJ
Format: Journal article
Language:English
Published: Oxford University Press 2022

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