Cytoplasmic location of factor-inhibiting hypoxia-inducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer.

INTRODUCTION: Hypoxia-inducible factor (HIF)-1alpha levels in invasive breast carcinoma have been shown to be an adverse prognostic indicator. Cellular HIF-1alpha activity is regulated by factor-inhibiting hypoxia-inducible factor 1 (FIH-1). In hypoxia, FIH-1 hydroxylation of Asn803 within the C-te...

詳細記述

書誌詳細
主要な著者: Tan, E, Campo, L, Han, C, Turley, H, Pezzella, F, Gatter, K, Harris, A, Fox, S
フォーマット: Journal article
言語:English
出版事項: 2007