Spiral artery blood volume in normal pregnancies and those compromised by pre-eclampsia.
The aim of this work was to use intravoxel incoherent motion (IVIM) to provide a non-invasive in vivo assessment of the function of the maternal spiral arteries that feed the placenta in normal pregnancy and in pre-eclampsia. Eleven normal pregnant women were scanned at 16, 22, 29 and 35 weeks gesta...
| Päätekijät: | , , , , , , , |
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| Aineistotyyppi: | Journal article |
| Kieli: | English |
| Julkaistu: |
2008
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| _version_ | 1826265661532274688 |
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| author | Moore, R Ong, S Tyler, D Duckett, R Baker, P Dunn, W Johnson, I Gowland, P |
| author_facet | Moore, R Ong, S Tyler, D Duckett, R Baker, P Dunn, W Johnson, I Gowland, P |
| author_sort | Moore, R |
| collection | OXFORD |
| description | The aim of this work was to use intravoxel incoherent motion (IVIM) to provide a non-invasive in vivo assessment of the function of the maternal spiral arteries that feed the placenta in normal pregnancy and in pre-eclampsia. Eleven normal pregnant women were scanned at 16, 22, 29 and 35 weeks gestation in a longitudinal study. Nine normal pregnant women and six women with pre-eclampsia were scanned in a cross-sectional study, within 10 days of delivery. The MRI IVIM technique was used to measure the moving blood fraction (f%) at the basal plate. There was no evidence that f% changed with gestational age (P = 0.84), but considering the cross-sectional groups, f% in women with pre-eclampsia was reduced compared with normal pregnancy (mean +/- SD: 36 +/- 5% and 27 +/- 5%; P < 0.005). In conclusion, pregnancies complicated by pre-eclampsia exhibit a reduced fraction of moving blood within the region of the spiral arteries. IVIM performed in the mid-trimester may provide an early means of predicting those pregnancies with an increased likelihood of being complicated by pre-eclampsia. |
| first_indexed | 2024-03-06T20:27:10Z |
| format | Journal article |
| id | oxford-uuid:2fc80c20-4b61-42e7-84e8-0cc2ff4d4009 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:27:10Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:2fc80c20-4b61-42e7-84e8-0cc2ff4d40092022-03-26T12:57:28ZSpiral artery blood volume in normal pregnancies and those compromised by pre-eclampsia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2fc80c20-4b61-42e7-84e8-0cc2ff4d4009EnglishSymplectic Elements at Oxford2008Moore, ROng, STyler, DDuckett, RBaker, PDunn, WJohnson, IGowland, PThe aim of this work was to use intravoxel incoherent motion (IVIM) to provide a non-invasive in vivo assessment of the function of the maternal spiral arteries that feed the placenta in normal pregnancy and in pre-eclampsia. Eleven normal pregnant women were scanned at 16, 22, 29 and 35 weeks gestation in a longitudinal study. Nine normal pregnant women and six women with pre-eclampsia were scanned in a cross-sectional study, within 10 days of delivery. The MRI IVIM technique was used to measure the moving blood fraction (f%) at the basal plate. There was no evidence that f% changed with gestational age (P = 0.84), but considering the cross-sectional groups, f% in women with pre-eclampsia was reduced compared with normal pregnancy (mean +/- SD: 36 +/- 5% and 27 +/- 5%; P < 0.005). In conclusion, pregnancies complicated by pre-eclampsia exhibit a reduced fraction of moving blood within the region of the spiral arteries. IVIM performed in the mid-trimester may provide an early means of predicting those pregnancies with an increased likelihood of being complicated by pre-eclampsia. |
| spellingShingle | Moore, R Ong, S Tyler, D Duckett, R Baker, P Dunn, W Johnson, I Gowland, P Spiral artery blood volume in normal pregnancies and those compromised by pre-eclampsia. |
| title | Spiral artery blood volume in normal pregnancies and those compromised by pre-eclampsia. |
| title_full | Spiral artery blood volume in normal pregnancies and those compromised by pre-eclampsia. |
| title_fullStr | Spiral artery blood volume in normal pregnancies and those compromised by pre-eclampsia. |
| title_full_unstemmed | Spiral artery blood volume in normal pregnancies and those compromised by pre-eclampsia. |
| title_short | Spiral artery blood volume in normal pregnancies and those compromised by pre-eclampsia. |
| title_sort | spiral artery blood volume in normal pregnancies and those compromised by pre eclampsia |
| work_keys_str_mv | AT moorer spiralarterybloodvolumeinnormalpregnanciesandthosecompromisedbypreeclampsia AT ongs spiralarterybloodvolumeinnormalpregnanciesandthosecompromisedbypreeclampsia AT tylerd spiralarterybloodvolumeinnormalpregnanciesandthosecompromisedbypreeclampsia AT duckettr spiralarterybloodvolumeinnormalpregnanciesandthosecompromisedbypreeclampsia AT bakerp spiralarterybloodvolumeinnormalpregnanciesandthosecompromisedbypreeclampsia AT dunnw spiralarterybloodvolumeinnormalpregnanciesandthosecompromisedbypreeclampsia AT johnsoni spiralarterybloodvolumeinnormalpregnanciesandthosecompromisedbypreeclampsia AT gowlandp spiralarterybloodvolumeinnormalpregnanciesandthosecompromisedbypreeclampsia |