Activin and follistatin in female reproduction.
Activin and follistatin were initially identified in the follicular fluid based on their effects on pituitary FSH secretion in the mid-1980s. It is now evident that activin, follistatin and activin receptors are widely expressed in many tissues where they function as autocrine/paracrine regulators o...
| Main Authors: | , , , |
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| Format: | Conference item |
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2004
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| _version_ | 1797061170321948672 |
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| author | Muttukrishna, S Tannetta, D Groome, N Sargent, I |
| author_facet | Muttukrishna, S Tannetta, D Groome, N Sargent, I |
| author_sort | Muttukrishna, S |
| collection | OXFORD |
| description | Activin and follistatin were initially identified in the follicular fluid based on their effects on pituitary FSH secretion in the mid-1980s. It is now evident that activin, follistatin and activin receptors are widely expressed in many tissues where they function as autocrine/paracrine regulators of a variety of physiological processes including reproduction. The major function of follistatin is to bind to activin with high affinity and block activin binding to its receptors. Total activin A and follistatin are also found in the maternal circulation throughout pregnancy. Activin A levels are increased in abnormal pregnancies such as pre-eclampsia, fetal growth restriction and gestational hypertension. The placenta, vascular endothelial cells and activated peripheral mononuclear cells (PBMC) may all contribute to the raised levels of activin A in pre-eclampsia with unaltered follistatin in pre-eclamptic placenta, PBMCs or vascular endothelial cells suggesting the availability of 'free' activin A that could be biologically active in these cells. |
| first_indexed | 2024-03-06T20:27:14Z |
| format | Conference item |
| id | oxford-uuid:2fcca486-de5c-4121-88b8-e86872f0e4de |
| institution | University of Oxford |
| last_indexed | 2024-03-06T20:27:14Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:2fcca486-de5c-4121-88b8-e86872f0e4de2022-03-26T12:57:36ZActivin and follistatin in female reproduction.Conference itemhttp://purl.org/coar/resource_type/c_5794uuid:2fcca486-de5c-4121-88b8-e86872f0e4deSymplectic Elements at Oxford2004Muttukrishna, STannetta, DGroome, NSargent, IActivin and follistatin were initially identified in the follicular fluid based on their effects on pituitary FSH secretion in the mid-1980s. It is now evident that activin, follistatin and activin receptors are widely expressed in many tissues where they function as autocrine/paracrine regulators of a variety of physiological processes including reproduction. The major function of follistatin is to bind to activin with high affinity and block activin binding to its receptors. Total activin A and follistatin are also found in the maternal circulation throughout pregnancy. Activin A levels are increased in abnormal pregnancies such as pre-eclampsia, fetal growth restriction and gestational hypertension. The placenta, vascular endothelial cells and activated peripheral mononuclear cells (PBMC) may all contribute to the raised levels of activin A in pre-eclampsia with unaltered follistatin in pre-eclamptic placenta, PBMCs or vascular endothelial cells suggesting the availability of 'free' activin A that could be biologically active in these cells. |
| spellingShingle | Muttukrishna, S Tannetta, D Groome, N Sargent, I Activin and follistatin in female reproduction. |
| title | Activin and follistatin in female reproduction. |
| title_full | Activin and follistatin in female reproduction. |
| title_fullStr | Activin and follistatin in female reproduction. |
| title_full_unstemmed | Activin and follistatin in female reproduction. |
| title_short | Activin and follistatin in female reproduction. |
| title_sort | activin and follistatin in female reproduction |
| work_keys_str_mv | AT muttukrishnas activinandfollistatininfemalereproduction AT tannettad activinandfollistatininfemalereproduction AT groomen activinandfollistatininfemalereproduction AT sargenti activinandfollistatininfemalereproduction |