Flagellum assembly and function during the Leishmania life cycle.
During a complex digenetic life cycle flagellated Leishmania parasites alternate between promastigote and amastigote forms which differ significantly in cellular morphology and flagellum length. Recent studies have provided important new insights into mechanisms by which Leishmania regulate expressi...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1797061172108722176 |
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| author | Gluenz, E Ginger, M McKean, P |
| author_facet | Gluenz, E Ginger, M McKean, P |
| author_sort | Gluenz, E |
| collection | OXFORD |
| description | During a complex digenetic life cycle flagellated Leishmania parasites alternate between promastigote and amastigote forms which differ significantly in cellular morphology and flagellum length. Recent studies have provided important new insights into mechanisms by which Leishmania regulate expression of genes required for flagellum assembly, and mechanisms used to modify flagellum length. While the critical role of the promastigote flagellum in parasite biology has long been appreciated, the importance of the amastigote flagellum has often been disregarded. However, recent work suggests that the 'rudimentary' amastigote flagellum may serve indispensable roles in cellular organisation, and/or sensory perception, which are critical for intracellular survival of Leishmania within host macrophages. |
| first_indexed | 2024-03-06T20:27:15Z |
| format | Journal article |
| id | oxford-uuid:2fcde910-5b9c-4268-a433-a090ea9f4122 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:27:15Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:2fcde910-5b9c-4268-a433-a090ea9f41222022-03-26T12:57:41ZFlagellum assembly and function during the Leishmania life cycle.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2fcde910-5b9c-4268-a433-a090ea9f4122EnglishSymplectic Elements at Oxford2010Gluenz, EGinger, MMcKean, PDuring a complex digenetic life cycle flagellated Leishmania parasites alternate between promastigote and amastigote forms which differ significantly in cellular morphology and flagellum length. Recent studies have provided important new insights into mechanisms by which Leishmania regulate expression of genes required for flagellum assembly, and mechanisms used to modify flagellum length. While the critical role of the promastigote flagellum in parasite biology has long been appreciated, the importance of the amastigote flagellum has often been disregarded. However, recent work suggests that the 'rudimentary' amastigote flagellum may serve indispensable roles in cellular organisation, and/or sensory perception, which are critical for intracellular survival of Leishmania within host macrophages. |
| spellingShingle | Gluenz, E Ginger, M McKean, P Flagellum assembly and function during the Leishmania life cycle. |
| title | Flagellum assembly and function during the Leishmania life cycle. |
| title_full | Flagellum assembly and function during the Leishmania life cycle. |
| title_fullStr | Flagellum assembly and function during the Leishmania life cycle. |
| title_full_unstemmed | Flagellum assembly and function during the Leishmania life cycle. |
| title_short | Flagellum assembly and function during the Leishmania life cycle. |
| title_sort | flagellum assembly and function during the leishmania life cycle |
| work_keys_str_mv | AT gluenze flagellumassemblyandfunctionduringtheleishmanialifecycle AT gingerm flagellumassemblyandfunctionduringtheleishmanialifecycle AT mckeanp flagellumassemblyandfunctionduringtheleishmanialifecycle |