Comparison of hypercapnia-based calibration techniques for measurement of cerebral oxygen metabolism with MRI.
MRI may be used to measure fractional changes in cerebral oxygen metabolism via a metabolic model. One step commonly used in this measurement is calibration with image data acquired during hypercapnia, which is a state of increased CO2 content of the blood. In this study some commonly used hypercapn...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2009
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| _version_ | 1797061217188052992 |
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| author | Bulte, D Drescher, K Jezzard, P |
| author_facet | Bulte, D Drescher, K Jezzard, P |
| author_sort | Bulte, D |
| collection | OXFORD |
| description | MRI may be used to measure fractional changes in cerebral oxygen metabolism via a metabolic model. One step commonly used in this measurement is calibration with image data acquired during hypercapnia, which is a state of increased CO2 content of the blood. In this study some commonly used hypercapnia-inducing stimuli were compared to assess their suitability for the calibration step. The following stimuli were investigated: (a) inspiration of a mixture of 4% CO2, 21% O2 and balance N2; (b) 30-s breath holding; and (c) inspiration of a mixture of 4% CO2 and 96% O2 (i.e., carbogen). Measurements of BOLD and cerebral blood flow made on nine subjects during the different hypercapnia-inducing stimuli showed that each stimulus leads to a different calibration of the model. We argue that of the aforementioned stimuli, inspiration of 4% CO2, 21% O2 and balance N2 should be preferred for the calibration as the other stimuli produce responses that violate assumptions of the metabolic model. |
| first_indexed | 2024-03-06T20:27:54Z |
| format | Journal article |
| id | oxford-uuid:3003f2c7-3610-4731-9bf9-2925bbb53399 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:27:54Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:3003f2c7-3610-4731-9bf9-2925bbb533992022-03-26T12:59:05ZComparison of hypercapnia-based calibration techniques for measurement of cerebral oxygen metabolism with MRI.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3003f2c7-3610-4731-9bf9-2925bbb53399EnglishSymplectic Elements at Oxford2009Bulte, DDrescher, KJezzard, PMRI may be used to measure fractional changes in cerebral oxygen metabolism via a metabolic model. One step commonly used in this measurement is calibration with image data acquired during hypercapnia, which is a state of increased CO2 content of the blood. In this study some commonly used hypercapnia-inducing stimuli were compared to assess their suitability for the calibration step. The following stimuli were investigated: (a) inspiration of a mixture of 4% CO2, 21% O2 and balance N2; (b) 30-s breath holding; and (c) inspiration of a mixture of 4% CO2 and 96% O2 (i.e., carbogen). Measurements of BOLD and cerebral blood flow made on nine subjects during the different hypercapnia-inducing stimuli showed that each stimulus leads to a different calibration of the model. We argue that of the aforementioned stimuli, inspiration of 4% CO2, 21% O2 and balance N2 should be preferred for the calibration as the other stimuli produce responses that violate assumptions of the metabolic model. |
| spellingShingle | Bulte, D Drescher, K Jezzard, P Comparison of hypercapnia-based calibration techniques for measurement of cerebral oxygen metabolism with MRI. |
| title | Comparison of hypercapnia-based calibration techniques for measurement of cerebral oxygen metabolism with MRI. |
| title_full | Comparison of hypercapnia-based calibration techniques for measurement of cerebral oxygen metabolism with MRI. |
| title_fullStr | Comparison of hypercapnia-based calibration techniques for measurement of cerebral oxygen metabolism with MRI. |
| title_full_unstemmed | Comparison of hypercapnia-based calibration techniques for measurement of cerebral oxygen metabolism with MRI. |
| title_short | Comparison of hypercapnia-based calibration techniques for measurement of cerebral oxygen metabolism with MRI. |
| title_sort | comparison of hypercapnia based calibration techniques for measurement of cerebral oxygen metabolism with mri |
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