A unique biphasic variant of cutaneous fibrous histiocytoma with a storiform pattern and intralesional pigmented melanocytes: "storiform melano-fibrous histiocytoma".
Dermatofibromas (cutaneous fibrous histiocytomas) are common cutaneous neoplasms of mesenchymal origin. They are often associated with epidermal hyperplasia and increased basal layer pigmentation. There have been reports of a spectrum of melanocytic lesions associated with dermatofibromas ranging fr...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2008
|
| _version_ | 1797061235261308928 |
|---|---|
| author | Nair, V Weinreb, I MacNeil, N Szollosi, Z Chetty, R Ghazarian, D |
| author_facet | Nair, V Weinreb, I MacNeil, N Szollosi, Z Chetty, R Ghazarian, D |
| author_sort | Nair, V |
| collection | OXFORD |
| description | Dermatofibromas (cutaneous fibrous histiocytomas) are common cutaneous neoplasms of mesenchymal origin. They are often associated with epidermal hyperplasia and increased basal layer pigmentation. There have been reports of a spectrum of melanocytic lesions associated with dermatofibromas ranging from junctional nevi to malignant melanomas, some of which may be coincidentally associated. We report a case of a long-standing storiform fibrohistiocytic lesion devoid of cytological atypia, lacking extension into subcutaneous fat, not demonstrating the t(17;22) DFSP translocation yet showing diffuse and strong CD34 immunoreactivity and containing pigmented spindle shaped melanocytic cells admixed with the fibrohistiocytic component. This case raises a nosological debate given the histological, immunophenotypic and cytogenetic findings. |
| first_indexed | 2024-03-06T20:28:10Z |
| format | Journal article |
| id | oxford-uuid:301ec11f-e085-49e6-afaf-93bdd125f4a0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:28:10Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:301ec11f-e085-49e6-afaf-93bdd125f4a02022-03-26T12:59:41ZA unique biphasic variant of cutaneous fibrous histiocytoma with a storiform pattern and intralesional pigmented melanocytes: "storiform melano-fibrous histiocytoma".Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:301ec11f-e085-49e6-afaf-93bdd125f4a0EnglishSymplectic Elements at Oxford2008Nair, VWeinreb, IMacNeil, NSzollosi, ZChetty, RGhazarian, DDermatofibromas (cutaneous fibrous histiocytomas) are common cutaneous neoplasms of mesenchymal origin. They are often associated with epidermal hyperplasia and increased basal layer pigmentation. There have been reports of a spectrum of melanocytic lesions associated with dermatofibromas ranging from junctional nevi to malignant melanomas, some of which may be coincidentally associated. We report a case of a long-standing storiform fibrohistiocytic lesion devoid of cytological atypia, lacking extension into subcutaneous fat, not demonstrating the t(17;22) DFSP translocation yet showing diffuse and strong CD34 immunoreactivity and containing pigmented spindle shaped melanocytic cells admixed with the fibrohistiocytic component. This case raises a nosological debate given the histological, immunophenotypic and cytogenetic findings. |
| spellingShingle | Nair, V Weinreb, I MacNeil, N Szollosi, Z Chetty, R Ghazarian, D A unique biphasic variant of cutaneous fibrous histiocytoma with a storiform pattern and intralesional pigmented melanocytes: "storiform melano-fibrous histiocytoma". |
| title | A unique biphasic variant of cutaneous fibrous histiocytoma with a storiform pattern and intralesional pigmented melanocytes: "storiform melano-fibrous histiocytoma". |
| title_full | A unique biphasic variant of cutaneous fibrous histiocytoma with a storiform pattern and intralesional pigmented melanocytes: "storiform melano-fibrous histiocytoma". |
| title_fullStr | A unique biphasic variant of cutaneous fibrous histiocytoma with a storiform pattern and intralesional pigmented melanocytes: "storiform melano-fibrous histiocytoma". |
| title_full_unstemmed | A unique biphasic variant of cutaneous fibrous histiocytoma with a storiform pattern and intralesional pigmented melanocytes: "storiform melano-fibrous histiocytoma". |
| title_short | A unique biphasic variant of cutaneous fibrous histiocytoma with a storiform pattern and intralesional pigmented melanocytes: "storiform melano-fibrous histiocytoma". |
| title_sort | unique biphasic variant of cutaneous fibrous histiocytoma with a storiform pattern and intralesional pigmented melanocytes storiform melano fibrous histiocytoma |
| work_keys_str_mv | AT nairv auniquebiphasicvariantofcutaneousfibroushistiocytomawithastoriformpatternandintralesionalpigmentedmelanocytesstoriformmelanofibroushistiocytoma AT weinrebi auniquebiphasicvariantofcutaneousfibroushistiocytomawithastoriformpatternandintralesionalpigmentedmelanocytesstoriformmelanofibroushistiocytoma AT macneiln auniquebiphasicvariantofcutaneousfibroushistiocytomawithastoriformpatternandintralesionalpigmentedmelanocytesstoriformmelanofibroushistiocytoma AT szollosiz auniquebiphasicvariantofcutaneousfibroushistiocytomawithastoriformpatternandintralesionalpigmentedmelanocytesstoriformmelanofibroushistiocytoma AT chettyr auniquebiphasicvariantofcutaneousfibroushistiocytomawithastoriformpatternandintralesionalpigmentedmelanocytesstoriformmelanofibroushistiocytoma AT ghazariand auniquebiphasicvariantofcutaneousfibroushistiocytomawithastoriformpatternandintralesionalpigmentedmelanocytesstoriformmelanofibroushistiocytoma AT nairv uniquebiphasicvariantofcutaneousfibroushistiocytomawithastoriformpatternandintralesionalpigmentedmelanocytesstoriformmelanofibroushistiocytoma AT weinrebi uniquebiphasicvariantofcutaneousfibroushistiocytomawithastoriformpatternandintralesionalpigmentedmelanocytesstoriformmelanofibroushistiocytoma AT macneiln uniquebiphasicvariantofcutaneousfibroushistiocytomawithastoriformpatternandintralesionalpigmentedmelanocytesstoriformmelanofibroushistiocytoma AT szollosiz uniquebiphasicvariantofcutaneousfibroushistiocytomawithastoriformpatternandintralesionalpigmentedmelanocytesstoriformmelanofibroushistiocytoma AT chettyr uniquebiphasicvariantofcutaneousfibroushistiocytomawithastoriformpatternandintralesionalpigmentedmelanocytesstoriformmelanofibroushistiocytoma AT ghazariand uniquebiphasicvariantofcutaneousfibroushistiocytomawithastoriformpatternandintralesionalpigmentedmelanocytesstoriformmelanofibroushistiocytoma |