Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies.

We have determined the crystal structures of thiazoloisoindolinone non-nucleoside inhibitors in complex with HIV-1 reverse transcriptase to high-resolution limits of 2.7 A (BM +21.1326) and 2. 52 A (BM +50.0934). We find that the binding modes of this series of inhibitors closely resemble that of &q...

Полное описание

Библиографические подробности
Главные авторы: Ren, J, Esnouf, R, Hopkins, A, Stuart, D, Stammers, D
Формат: Journal article
Язык:English
Опубликовано: 1999