Epidemiology and virology of acute respiratory infections during the first year of life: a birth cohort study in Vietnam
Understanding viral etiology and age-specific incidence of acute respiratory infections in infants can help identify risk groups and inform vaccine delivery, but community-based data is lacking from tropical settings.One thousand four hundred and seventy-eight infants in urban Ho Chi Minh City and 9...
| Автори: | , , , , , , , , , , , , |
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| Формат: | Journal article |
| Мова: | English |
| Опубліковано: |
Lippincott, Williams & Wilkins
2015
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| _version_ | 1826265750102343680 |
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| author | Anders, K Nguyen, H Nguyen, N Van Thuy, N Hong Van, N Hieu, N Hong Tham, N Thanh Ha, P Lien, L Vinh Chau, N Ty Hang, V van Doorn, H Simmons, C |
| author_facet | Anders, K Nguyen, H Nguyen, N Van Thuy, N Hong Van, N Hieu, N Hong Tham, N Thanh Ha, P Lien, L Vinh Chau, N Ty Hang, V van Doorn, H Simmons, C |
| author_sort | Anders, K |
| collection | OXFORD |
| description | Understanding viral etiology and age-specific incidence of acute respiratory infections in infants can help identify risk groups and inform vaccine delivery, but community-based data is lacking from tropical settings.One thousand four hundred and seventy-eight infants in urban Ho Chi Minh City and 981 infants in a semi-rural district in southern Vietnam were enrolled at birth and followed to 1 year of age. Acute respiratory infection (ARI) episodes were identified through clinic-based illness surveillance, hospital admissions and self-reports. Nasopharyngeal swabs were collected from infants with respiratory symptoms and tested for 14 respiratory pathogens using multiplex reverse transcription-polymerase chain reaction.Estimated incidence of ARI was 542 and 2691 per 1000 infant-years, and hospitalization rates for ARI were 81 and 138 per 1000 infant-years, in urban and semi-rural cohorts, respectively, from clinic- and hospital-based surveillance. However self-reported ARI episodes were just 1.5-fold higher in the semi-rural versus urban cohort, indicating that part of the urban-rural difference was explained by under-ascertainment in the urban cohort. Incidence was higher in infants ≥6 months of age than <6 months, but this was pathogen-specific. One or more viruses were detected in 53% (urban) and 64% (semi-rural) of samples from outpatients with ARI and in 78% and 66% of samples from hospitalized ARI patients, respectively. The most frequently detected viruses were rhinovirus, respiratory syncytial virus, influenza virus A and bocavirus. ARI-associated hospitalizations were associated with longer stays and more frequent ICU admission than other infections.ARI is a significant cause of morbidity in Vietnamese infants and influenza virus A is an under-appreciated cause of vaccine-preventable disease and hospitalizations in this tropical setting. Public health strategies to reduce infant ARI incidence and hospitalization rates are needed. |
| first_indexed | 2024-03-06T20:28:33Z |
| format | Journal article |
| id | oxford-uuid:3043a74b-3e0a-430e-9f94-79b4baefe7d0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:28:33Z |
| publishDate | 2015 |
| publisher | Lippincott, Williams & Wilkins |
| record_format | dspace |
| spelling | oxford-uuid:3043a74b-3e0a-430e-9f94-79b4baefe7d02022-03-26T13:00:20ZEpidemiology and virology of acute respiratory infections during the first year of life: a birth cohort study in VietnamJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3043a74b-3e0a-430e-9f94-79b4baefe7d0EnglishSymplectic Elements at OxfordLippincott, Williams & Wilkins2015Anders, KNguyen, HNguyen, NVan Thuy, NHong Van, NHieu, NHong Tham, NThanh Ha, PLien, LVinh Chau, NTy Hang, Vvan Doorn, HSimmons, CUnderstanding viral etiology and age-specific incidence of acute respiratory infections in infants can help identify risk groups and inform vaccine delivery, but community-based data is lacking from tropical settings.One thousand four hundred and seventy-eight infants in urban Ho Chi Minh City and 981 infants in a semi-rural district in southern Vietnam were enrolled at birth and followed to 1 year of age. Acute respiratory infection (ARI) episodes were identified through clinic-based illness surveillance, hospital admissions and self-reports. Nasopharyngeal swabs were collected from infants with respiratory symptoms and tested for 14 respiratory pathogens using multiplex reverse transcription-polymerase chain reaction.Estimated incidence of ARI was 542 and 2691 per 1000 infant-years, and hospitalization rates for ARI were 81 and 138 per 1000 infant-years, in urban and semi-rural cohorts, respectively, from clinic- and hospital-based surveillance. However self-reported ARI episodes were just 1.5-fold higher in the semi-rural versus urban cohort, indicating that part of the urban-rural difference was explained by under-ascertainment in the urban cohort. Incidence was higher in infants ≥6 months of age than <6 months, but this was pathogen-specific. One or more viruses were detected in 53% (urban) and 64% (semi-rural) of samples from outpatients with ARI and in 78% and 66% of samples from hospitalized ARI patients, respectively. The most frequently detected viruses were rhinovirus, respiratory syncytial virus, influenza virus A and bocavirus. ARI-associated hospitalizations were associated with longer stays and more frequent ICU admission than other infections.ARI is a significant cause of morbidity in Vietnamese infants and influenza virus A is an under-appreciated cause of vaccine-preventable disease and hospitalizations in this tropical setting. Public health strategies to reduce infant ARI incidence and hospitalization rates are needed. |
| spellingShingle | Anders, K Nguyen, H Nguyen, N Van Thuy, N Hong Van, N Hieu, N Hong Tham, N Thanh Ha, P Lien, L Vinh Chau, N Ty Hang, V van Doorn, H Simmons, C Epidemiology and virology of acute respiratory infections during the first year of life: a birth cohort study in Vietnam |
| title | Epidemiology and virology of acute respiratory infections during the first year of life: a birth cohort study in Vietnam |
| title_full | Epidemiology and virology of acute respiratory infections during the first year of life: a birth cohort study in Vietnam |
| title_fullStr | Epidemiology and virology of acute respiratory infections during the first year of life: a birth cohort study in Vietnam |
| title_full_unstemmed | Epidemiology and virology of acute respiratory infections during the first year of life: a birth cohort study in Vietnam |
| title_short | Epidemiology and virology of acute respiratory infections during the first year of life: a birth cohort study in Vietnam |
| title_sort | epidemiology and virology of acute respiratory infections during the first year of life a birth cohort study in vietnam |
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