Halting of caspase activity protects tau from MC1-conformational change and aggregation
Intracellular neurofibrillary tangles (NFTs) are the hallmark of Alzheimer’s disease and other tauopathies in which tau, a microtubule-associated protein, loses its ability to stabilize microtubules. Several post-translational modifications including phosphorylation and truncation increase tau’s pro...
| Autori principali: | , , , , , , , , , , , |
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| Natura: | Journal article |
| Pubblicazione: |
IOS Press
2016
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