Definition of a population of CD4-8- T cells that express the alpha beta T-cell receptor and respond to interleukins 2, 3, and 4.
Whereas most T cells express surface CD4 or CD8 molecules, a minority lacks both. CD4-8- cells usually express the gamma delta T-cell receptor, but here we describe a population of CD4-8- T cells from the peripheral blood that express the alpha beta heterodimer. These cells have different surface an...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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1989
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| _version_ | 1826265762203959296 |
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| author | Londei, M Verhoef, A De Berardinis, P Kissonerghis, M Grubeck-Loebenstein, B Feldmann, M |
| author_facet | Londei, M Verhoef, A De Berardinis, P Kissonerghis, M Grubeck-Loebenstein, B Feldmann, M |
| author_sort | Londei, M |
| collection | OXFORD |
| description | Whereas most T cells express surface CD4 or CD8 molecules, a minority lacks both. CD4-8- cells usually express the gamma delta T-cell receptor, but here we describe a population of CD4-8- T cells from the peripheral blood that express the alpha beta heterodimer. These cells have different surface antigens than gamma delta+ T cells, expressing CD5 but lacking CD16, and differ in function from gamma delta+ T cells. CD4-8- alpha beta+ cells lack non-major histocompatibility complex-restricted cytolytic function but can be induced to lyse their target cells after activation of their T-cell receptors. A peculiar characteristic of these cells is their responsiveness to interleukin 3. Since these cells have not altered their phenotype or function over a 12-month period in culture, they appear to be mature T cells. The results indicate that normal human peripheral blood contains two subsets of CD4-8- T cells, expressing either gamma delta or alpha beta receptors, that differ in function, phenotype, and growth control. |
| first_indexed | 2024-03-06T20:28:43Z |
| format | Journal article |
| id | oxford-uuid:30518f9b-33d4-4edb-a9c2-922d3f817f73 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:28:43Z |
| publishDate | 1989 |
| record_format | dspace |
| spelling | oxford-uuid:30518f9b-33d4-4edb-a9c2-922d3f817f732022-03-26T13:00:42ZDefinition of a population of CD4-8- T cells that express the alpha beta T-cell receptor and respond to interleukins 2, 3, and 4.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:30518f9b-33d4-4edb-a9c2-922d3f817f73EnglishSymplectic Elements at Oxford1989Londei, MVerhoef, ADe Berardinis, PKissonerghis, MGrubeck-Loebenstein, BFeldmann, MWhereas most T cells express surface CD4 or CD8 molecules, a minority lacks both. CD4-8- cells usually express the gamma delta T-cell receptor, but here we describe a population of CD4-8- T cells from the peripheral blood that express the alpha beta heterodimer. These cells have different surface antigens than gamma delta+ T cells, expressing CD5 but lacking CD16, and differ in function from gamma delta+ T cells. CD4-8- alpha beta+ cells lack non-major histocompatibility complex-restricted cytolytic function but can be induced to lyse their target cells after activation of their T-cell receptors. A peculiar characteristic of these cells is their responsiveness to interleukin 3. Since these cells have not altered their phenotype or function over a 12-month period in culture, they appear to be mature T cells. The results indicate that normal human peripheral blood contains two subsets of CD4-8- T cells, expressing either gamma delta or alpha beta receptors, that differ in function, phenotype, and growth control. |
| spellingShingle | Londei, M Verhoef, A De Berardinis, P Kissonerghis, M Grubeck-Loebenstein, B Feldmann, M Definition of a population of CD4-8- T cells that express the alpha beta T-cell receptor and respond to interleukins 2, 3, and 4. |
| title | Definition of a population of CD4-8- T cells that express the alpha beta T-cell receptor and respond to interleukins 2, 3, and 4. |
| title_full | Definition of a population of CD4-8- T cells that express the alpha beta T-cell receptor and respond to interleukins 2, 3, and 4. |
| title_fullStr | Definition of a population of CD4-8- T cells that express the alpha beta T-cell receptor and respond to interleukins 2, 3, and 4. |
| title_full_unstemmed | Definition of a population of CD4-8- T cells that express the alpha beta T-cell receptor and respond to interleukins 2, 3, and 4. |
| title_short | Definition of a population of CD4-8- T cells that express the alpha beta T-cell receptor and respond to interleukins 2, 3, and 4. |
| title_sort | definition of a population of cd4 8 t cells that express the alpha beta t cell receptor and respond to interleukins 2 3 and 4 |
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