SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development

SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development

<p>SCF (Skp1-Cul1-F-box protein) ubiquitin ligases direct cell survival decisions by controlling protein ubiquitylation and degradation. Sufu (Suppressor of fused) is a central regulator of Hh (Hedgehog) signaling and acts as a tumour suppressor by maintaining the Gli (Glioma-associated oncoge...

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Autores principales: D'Angiolella, V, Raducu, M, Fung, E, Sebastien, S, Infante, P, Alessandro, B, Fischer, R, Bristow, C, Marie-Laetitia, T, Finta, C, Christianson, J, Francesca, B, Benedikt, K, Sibson, N, Di Marcotullio, L, Toftgard, R, Serres, S, Barberis, A, Thezenas, M, Csaba, F, Buffa, F, Kessler, B
Formato: Journal article
Publicado: EMBO Press 2016

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