SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development
<p>SCF (Skp1-Cul1-F-box protein) ubiquitin ligases direct cell survival decisions by controlling protein ubiquitylation and degradation. Sufu (Suppressor of fused) is a central regulator of Hh (Hedgehog) signaling and acts as a tumour suppressor by maintaining the Gli (Glioma-associated oncoge...
المؤلفون الرئيسيون: | , , , , , , , , , , , , , , , , , , , , , |
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التنسيق: | Journal article |
منشور في: |
EMBO Press
2016
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