Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators.

Míreanna comhchosúla

• NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.
  de réir: Smith, C, et al.
  Foilsithe / Cruthaithe: (2001)
• Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?
  de réir: Feldmann, M, et al.
  Foilsithe / Cruthaithe: (2002)
• Antigen-specific T-cell downregulation by human dendritic cells following blockade of NF-kappaB.
  de réir: Calder, V, et al.
  Foilsithe / Cruthaithe: (2003)
• Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines.
  de réir: Yoshimura, S, et al.
  Foilsithe / Cruthaithe: (2001)
• Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant.
  de réir: Andreakos, E, et al.
  Foilsithe / Cruthaithe: (2006)