Targeted T1 Magnetic Resonance Imaging Contrast Enhancement with Extraordinarily Small CoFe2O4 Nanoparticles
Extraordinarily small (2.4 nm) cobalt-ferrite nanoparticles (ESCIoNs) were synthesised by a one-pot thermal decomposition approach to study their potential as MRI contrast agents. Fine size control was achieved using oleylamine alone, and annular dark-field scanning transmission electron microscopy...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
American Chemical Society
2019
|
| _version_ | 1797061312825524224 |
|---|---|
| author | Piché, D Tavernaro, I Fleddermann, J Lozano, J Varambhia, A Maguire, M Koch, M Ukai, T Rodríguez, A Jones, L Dillon, F Molina, I Mitzutani, M Dalmau, E Maekawa, T Nellist, P Kraegeloh, A Grobert, N |
| author_facet | Piché, D Tavernaro, I Fleddermann, J Lozano, J Varambhia, A Maguire, M Koch, M Ukai, T Rodríguez, A Jones, L Dillon, F Molina, I Mitzutani, M Dalmau, E Maekawa, T Nellist, P Kraegeloh, A Grobert, N |
| author_sort | Piché, D |
| collection | OXFORD |
| description | Extraordinarily small (2.4 nm) cobalt-ferrite nanoparticles (ESCIoNs) were synthesised by a one-pot thermal decomposition approach to study their potential as MRI contrast agents. Fine size control was achieved using oleylamine alone, and annular dark-field scanning transmission electron microscopy revealed highly-crystalline cubic spinel particles with atomic-resolution. Ligand exchange with dimercaptosuccinic acid rendered the particles stable in physiological conditions with a hydrodynamic diameter of ∽12 nm. The particles displayed superparamagnetic properties, and a low r2/ r1 ratio suitable for a T1 contrast agent. The particles were functionalised with bile-acid which improved biocompatibility by significant reduction of reactive oxygen species generation and is a first step towards liver-targeted T1 MRI. Our study demonstrates the potential of ESCIoNs as T1 MRI contrast agents. |
| first_indexed | 2024-03-06T20:29:18Z |
| format | Journal article |
| id | oxford-uuid:308399ca-3cb8-4cd1-89fb-b4639ced46ea |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:29:18Z |
| publishDate | 2019 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | oxford-uuid:308399ca-3cb8-4cd1-89fb-b4639ced46ea2022-03-26T13:01:54ZTargeted T1 Magnetic Resonance Imaging Contrast Enhancement with Extraordinarily Small CoFe2O4 NanoparticlesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:308399ca-3cb8-4cd1-89fb-b4639ced46eaEnglishSymplectic Elements at OxfordAmerican Chemical Society2019Piché, DTavernaro, IFleddermann, JLozano, JVarambhia, AMaguire, MKoch, MUkai, TRodríguez, AJones, LDillon, FMolina, IMitzutani, MDalmau, EMaekawa, TNellist, PKraegeloh, AGrobert, NExtraordinarily small (2.4 nm) cobalt-ferrite nanoparticles (ESCIoNs) were synthesised by a one-pot thermal decomposition approach to study their potential as MRI contrast agents. Fine size control was achieved using oleylamine alone, and annular dark-field scanning transmission electron microscopy revealed highly-crystalline cubic spinel particles with atomic-resolution. Ligand exchange with dimercaptosuccinic acid rendered the particles stable in physiological conditions with a hydrodynamic diameter of ∽12 nm. The particles displayed superparamagnetic properties, and a low r2/ r1 ratio suitable for a T1 contrast agent. The particles were functionalised with bile-acid which improved biocompatibility by significant reduction of reactive oxygen species generation and is a first step towards liver-targeted T1 MRI. Our study demonstrates the potential of ESCIoNs as T1 MRI contrast agents. |
| spellingShingle | Piché, D Tavernaro, I Fleddermann, J Lozano, J Varambhia, A Maguire, M Koch, M Ukai, T Rodríguez, A Jones, L Dillon, F Molina, I Mitzutani, M Dalmau, E Maekawa, T Nellist, P Kraegeloh, A Grobert, N Targeted T1 Magnetic Resonance Imaging Contrast Enhancement with Extraordinarily Small CoFe2O4 Nanoparticles |
| title | Targeted T1 Magnetic Resonance Imaging Contrast Enhancement with Extraordinarily Small CoFe2O4 Nanoparticles |
| title_full | Targeted T1 Magnetic Resonance Imaging Contrast Enhancement with Extraordinarily Small CoFe2O4 Nanoparticles |
| title_fullStr | Targeted T1 Magnetic Resonance Imaging Contrast Enhancement with Extraordinarily Small CoFe2O4 Nanoparticles |
| title_full_unstemmed | Targeted T1 Magnetic Resonance Imaging Contrast Enhancement with Extraordinarily Small CoFe2O4 Nanoparticles |
| title_short | Targeted T1 Magnetic Resonance Imaging Contrast Enhancement with Extraordinarily Small CoFe2O4 Nanoparticles |
| title_sort | targeted t1 magnetic resonance imaging contrast enhancement with extraordinarily small cofe2o4 nanoparticles |
| work_keys_str_mv | AT piched targetedt1magneticresonanceimagingcontrastenhancementwithextraordinarilysmallcofe2o4nanoparticles AT tavernaroi targetedt1magneticresonanceimagingcontrastenhancementwithextraordinarilysmallcofe2o4nanoparticles AT fleddermannj targetedt1magneticresonanceimagingcontrastenhancementwithextraordinarilysmallcofe2o4nanoparticles AT lozanoj targetedt1magneticresonanceimagingcontrastenhancementwithextraordinarilysmallcofe2o4nanoparticles AT varambhiaa targetedt1magneticresonanceimagingcontrastenhancementwithextraordinarilysmallcofe2o4nanoparticles AT maguirem targetedt1magneticresonanceimagingcontrastenhancementwithextraordinarilysmallcofe2o4nanoparticles AT kochm targetedt1magneticresonanceimagingcontrastenhancementwithextraordinarilysmallcofe2o4nanoparticles AT ukait targetedt1magneticresonanceimagingcontrastenhancementwithextraordinarilysmallcofe2o4nanoparticles AT rodrigueza targetedt1magneticresonanceimagingcontrastenhancementwithextraordinarilysmallcofe2o4nanoparticles AT jonesl targetedt1magneticresonanceimagingcontrastenhancementwithextraordinarilysmallcofe2o4nanoparticles AT dillonf targetedt1magneticresonanceimagingcontrastenhancementwithextraordinarilysmallcofe2o4nanoparticles AT molinai targetedt1magneticresonanceimagingcontrastenhancementwithextraordinarilysmallcofe2o4nanoparticles AT mitzutanim targetedt1magneticresonanceimagingcontrastenhancementwithextraordinarilysmallcofe2o4nanoparticles AT dalmaue targetedt1magneticresonanceimagingcontrastenhancementwithextraordinarilysmallcofe2o4nanoparticles AT maekawat targetedt1magneticresonanceimagingcontrastenhancementwithextraordinarilysmallcofe2o4nanoparticles AT nellistp targetedt1magneticresonanceimagingcontrastenhancementwithextraordinarilysmallcofe2o4nanoparticles AT kraegeloha targetedt1magneticresonanceimagingcontrastenhancementwithextraordinarilysmallcofe2o4nanoparticles AT grobertn targetedt1magneticresonanceimagingcontrastenhancementwithextraordinarilysmallcofe2o4nanoparticles |