Cardiomyocyte Na+/H+ exchanger-1 activity is reduced in hypoxia

Cardiomyocyte Na+/H+ exchanger-1 activity is reduced in hypoxia

Fully-activated Na+/H+ exchanger-1 (NHE1) generates the cardiomyocyte’s largest trans-membrane extrusion of H+ ions for an equimolar influx of Na+ ions. This has the desirable effect of clearing excess intracellular acidity, but at a large energetic premium because the exchanged Na+ ions must ultima...

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Detalhes bibliográficos
Main Authors:	Kandilci, H, Richards, M, Swietach, P
Formato:	Journal article
Idioma:	English
Publicado em:	Frontiers Media 2021

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