Anatomic position determines oncogenic specificity in melanoma

Oncogenic alterations to DNA are not transforming in all cellular contexts1,2. This may be due to pre-existing transcriptional programmes in the cell of origin. Here we define anatomic position as a major determinant of why cells respond to specific oncogenes. Cutaneous melanoma arises throughout th...

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Dettagli Bibliografici
Autori principali:	Weiss, JM, Hunter, MV, Cruz, NM, Baggiolini, A, Tagore, M, Ma, Y, Misale, S, Marasco, M, Simon-Vermot, T, Campbell, NR, Newell, F, Wilmott, JS, Johansson, PA, Thompson, JF, Long, GV, Pearson, JV, Mann, GJ, Scolyer, RA, Waddell, N, Montal, ED, Huang, T-H, Jonsson, P, Donoghue, MTA, Harris, CC, Taylor, BS, Xu, T, Chaligné, R, Shliaha, PV, Hendrickson, R, Jungbluth, AA, Lezcano, C, Koche, R, Studer, L, Ariyan, CE, Solit, DB, Wolchok, JD, Merghoub, T, Rosen, N, Hayward, NK, White, RM
Natura:	Journal article
Lingua:	English
Pubblicazione:	Springer Nature 2022

Anatomic position determines oncogenic specificity in melanoma

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