m-Chlorophenylpiperazine decreases food intake in a test meal.
We studied the effect of the 5-HT receptor agonist, m-chlorophenylpiperazine (mCPP) (0.4 mg/kg), on food intake in 12 healthy female volunteers, in a double-blind placebo controlled design. Compared to placebo, mCPP significantly lowered food intake in a test meal. Treatment with mCPP also caused si...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1994
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| _version_ | 1797061332963426304 |
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| author | Walsh, A Smith, K Oldman, A Williams, C Goodall, E Cowen, P |
| author_facet | Walsh, A Smith, K Oldman, A Williams, C Goodall, E Cowen, P |
| author_sort | Walsh, A |
| collection | OXFORD |
| description | We studied the effect of the 5-HT receptor agonist, m-chlorophenylpiperazine (mCPP) (0.4 mg/kg), on food intake in 12 healthy female volunteers, in a double-blind placebo controlled design. Compared to placebo, mCPP significantly lowered food intake in a test meal. Treatment with mCPP also caused significant increases in ratings of nausea and light-headedness, though these effects had remitted by the time of the test meal. The results suggest that activation of brain 5-HT2C receptors may lower food intake in humans; it is also possible, however, that the hypophagic effect of mCPP in the present study could be a consequence of its adverse subjective side effects. |
| first_indexed | 2024-03-06T20:29:36Z |
| format | Journal article |
| id | oxford-uuid:309b2552-e336-4f3a-bd9f-8f8470533f34 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:29:36Z |
| publishDate | 1994 |
| record_format | dspace |
| spelling | oxford-uuid:309b2552-e336-4f3a-bd9f-8f8470533f342022-03-26T13:02:25Zm-Chlorophenylpiperazine decreases food intake in a test meal.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:309b2552-e336-4f3a-bd9f-8f8470533f34EnglishSymplectic Elements at Oxford1994Walsh, ASmith, KOldman, AWilliams, CGoodall, ECowen, PWe studied the effect of the 5-HT receptor agonist, m-chlorophenylpiperazine (mCPP) (0.4 mg/kg), on food intake in 12 healthy female volunteers, in a double-blind placebo controlled design. Compared to placebo, mCPP significantly lowered food intake in a test meal. Treatment with mCPP also caused significant increases in ratings of nausea and light-headedness, though these effects had remitted by the time of the test meal. The results suggest that activation of brain 5-HT2C receptors may lower food intake in humans; it is also possible, however, that the hypophagic effect of mCPP in the present study could be a consequence of its adverse subjective side effects. |
| spellingShingle | Walsh, A Smith, K Oldman, A Williams, C Goodall, E Cowen, P m-Chlorophenylpiperazine decreases food intake in a test meal. |
| title | m-Chlorophenylpiperazine decreases food intake in a test meal. |
| title_full | m-Chlorophenylpiperazine decreases food intake in a test meal. |
| title_fullStr | m-Chlorophenylpiperazine decreases food intake in a test meal. |
| title_full_unstemmed | m-Chlorophenylpiperazine decreases food intake in a test meal. |
| title_short | m-Chlorophenylpiperazine decreases food intake in a test meal. |
| title_sort | m chlorophenylpiperazine decreases food intake in a test meal |
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