A high-resolution single nucleotide polymorphism genetic map of the mouse genome
High-resolution genetic maps are required for mapping complex traits and for the study of recombination. We report the highest density genetic map yet created for any organism, except humans. Using more than 10,000 single nucleotide polymorphisms evenly spaced across the mouse genome, we have constr...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Journal article |
| Language: | English |
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Public Library of Science
2006
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| Subjects: |
| _version_ | 1826265824335233024 |
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| author | Shifman, S Bell, J Copley, R Taylor, M Williams, R Mott, R Flint, J |
| author2 | Gibbs, R |
| author_facet | Gibbs, R Shifman, S Bell, J Copley, R Taylor, M Williams, R Mott, R Flint, J |
| author_sort | Shifman, S |
| collection | OXFORD |
| description | High-resolution genetic maps are required for mapping complex traits and for the study of recombination. We report the highest density genetic map yet created for any organism, except humans. Using more than 10,000 single nucleotide polymorphisms evenly spaced across the mouse genome, we have constructed genetic maps for both outbred and inbred mice, and separately for males and females. Recombination rates are highly correlated in outbred and inbred mice, but show relatively low correlation between males and females. Differences between male and female recombination maps and the sequence features associated with recombination are strikingly similar to those observed in humans. Genetic maps are available from http://gscan.well.ox.ac.uk/#genetic_map and as supporting information to this publication. |
| first_indexed | 2024-03-06T20:29:40Z |
| format | Journal article |
| id | oxford-uuid:309f1b7d-5b72-47e6-be73-b255a794262a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:29:40Z |
| publishDate | 2006 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:309f1b7d-5b72-47e6-be73-b255a794262a2022-03-26T13:02:42ZA high-resolution single nucleotide polymorphism genetic map of the mouse genomeJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:309f1b7d-5b72-47e6-be73-b255a794262aGenetics (medical sciences)EnglishOxford University Research Archive - ValetPublic Library of Science2006Shifman, SBell, JCopley, RTaylor, MWilliams, RMott, RFlint, JGibbs, RHigh-resolution genetic maps are required for mapping complex traits and for the study of recombination. We report the highest density genetic map yet created for any organism, except humans. Using more than 10,000 single nucleotide polymorphisms evenly spaced across the mouse genome, we have constructed genetic maps for both outbred and inbred mice, and separately for males and females. Recombination rates are highly correlated in outbred and inbred mice, but show relatively low correlation between males and females. Differences between male and female recombination maps and the sequence features associated with recombination are strikingly similar to those observed in humans. Genetic maps are available from http://gscan.well.ox.ac.uk/#genetic_map and as supporting information to this publication. |
| spellingShingle | Genetics (medical sciences) Shifman, S Bell, J Copley, R Taylor, M Williams, R Mott, R Flint, J A high-resolution single nucleotide polymorphism genetic map of the mouse genome |
| title | A high-resolution single nucleotide polymorphism genetic map of the mouse genome |
| title_full | A high-resolution single nucleotide polymorphism genetic map of the mouse genome |
| title_fullStr | A high-resolution single nucleotide polymorphism genetic map of the mouse genome |
| title_full_unstemmed | A high-resolution single nucleotide polymorphism genetic map of the mouse genome |
| title_short | A high-resolution single nucleotide polymorphism genetic map of the mouse genome |
| title_sort | high resolution single nucleotide polymorphism genetic map of the mouse genome |
| topic | Genetics (medical sciences) |
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