Pharmacogenomics in colorectal cancer: A genome-wide association study to predict toxicity after 5-fluorouracil or FOLFOX administration
The development of genotyping technologies has allowed for wider screening for inherited causes of variable outcomes following drug administration. We have performed a genome-wide association study (GWAS) on 221 colorectal cancer (CRC) patients that had been treated with 5-fluorouracil (5-FU), eithe...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| פורמט: | Journal article |
| שפה: | English |
| יצא לאור: |
2013
|
| _version_ | 1826265867846942720 |
|---|---|
| author | Fernandez-Rozadilla, C Cazier, J Moreno, V Crous-Bou, M Guinó, E Durán, G Lamas, M López, R Candamio, S Gallardo, E Paré, L Baiget, M Páez, D López-Fernández, L Cortejoso, L García, M Bujanda, L González, D Gonzalo, V Rodrigo, L Reñé, J Jover, R Brea-Fernández, A Andreu, M Bessa, X |
| author_facet | Fernandez-Rozadilla, C Cazier, J Moreno, V Crous-Bou, M Guinó, E Durán, G Lamas, M López, R Candamio, S Gallardo, E Paré, L Baiget, M Páez, D López-Fernández, L Cortejoso, L García, M Bujanda, L González, D Gonzalo, V Rodrigo, L Reñé, J Jover, R Brea-Fernández, A Andreu, M Bessa, X |
| author_sort | Fernandez-Rozadilla, C |
| collection | OXFORD |
| description | The development of genotyping technologies has allowed for wider screening for inherited causes of variable outcomes following drug administration. We have performed a genome-wide association study (GWAS) on 221 colorectal cancer (CRC) patients that had been treated with 5-fluorouracil (5-FU), either alone or in combination with oxaliplatin (FOLFOX). A validation set of 791 patients was also studied. Seven SNPs (rs16857540, rs2465403, rs10876844, rs10784749, rs17626122, rs7325568 and rs4243761) showed evidence of association (pooled P-values 0.020, 9.426E-03, 0.010, 0.017, 0.042, 2.302E-04, 2.803E-03) with adverse drug reactions (ADRs). This is the first study to explore the genetic basis of inter-individual variation in toxicity responses to the administration of 5-FU or FOLFOX in CRC patients on a genome-wide scale. © 2013 Macmillan Publishers Limited. All rights reserved 1470-269X/13. |
| first_indexed | 2024-03-06T20:30:21Z |
| format | Journal article |
| id | oxford-uuid:30d4b76e-aa26-4ee4-8717-2eed8c12cbb3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:30:21Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:30d4b76e-aa26-4ee4-8717-2eed8c12cbb32022-03-26T13:04:01ZPharmacogenomics in colorectal cancer: A genome-wide association study to predict toxicity after 5-fluorouracil or FOLFOX administrationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:30d4b76e-aa26-4ee4-8717-2eed8c12cbb3EnglishSymplectic Elements at Oxford2013Fernandez-Rozadilla, CCazier, JMoreno, VCrous-Bou, MGuinó, EDurán, GLamas, MLópez, RCandamio, SGallardo, EParé, LBaiget, MPáez, DLópez-Fernández, LCortejoso, LGarcía, MBujanda, LGonzález, DGonzalo, VRodrigo, LReñé, JJover, RBrea-Fernández, AAndreu, MBessa, XThe development of genotyping technologies has allowed for wider screening for inherited causes of variable outcomes following drug administration. We have performed a genome-wide association study (GWAS) on 221 colorectal cancer (CRC) patients that had been treated with 5-fluorouracil (5-FU), either alone or in combination with oxaliplatin (FOLFOX). A validation set of 791 patients was also studied. Seven SNPs (rs16857540, rs2465403, rs10876844, rs10784749, rs17626122, rs7325568 and rs4243761) showed evidence of association (pooled P-values 0.020, 9.426E-03, 0.010, 0.017, 0.042, 2.302E-04, 2.803E-03) with adverse drug reactions (ADRs). This is the first study to explore the genetic basis of inter-individual variation in toxicity responses to the administration of 5-FU or FOLFOX in CRC patients on a genome-wide scale. © 2013 Macmillan Publishers Limited. All rights reserved 1470-269X/13. |
| spellingShingle | Fernandez-Rozadilla, C Cazier, J Moreno, V Crous-Bou, M Guinó, E Durán, G Lamas, M López, R Candamio, S Gallardo, E Paré, L Baiget, M Páez, D López-Fernández, L Cortejoso, L García, M Bujanda, L González, D Gonzalo, V Rodrigo, L Reñé, J Jover, R Brea-Fernández, A Andreu, M Bessa, X Pharmacogenomics in colorectal cancer: A genome-wide association study to predict toxicity after 5-fluorouracil or FOLFOX administration |
| title | Pharmacogenomics in colorectal cancer: A genome-wide association study to predict toxicity after 5-fluorouracil or FOLFOX administration |
| title_full | Pharmacogenomics in colorectal cancer: A genome-wide association study to predict toxicity after 5-fluorouracil or FOLFOX administration |
| title_fullStr | Pharmacogenomics in colorectal cancer: A genome-wide association study to predict toxicity after 5-fluorouracil or FOLFOX administration |
| title_full_unstemmed | Pharmacogenomics in colorectal cancer: A genome-wide association study to predict toxicity after 5-fluorouracil or FOLFOX administration |
| title_short | Pharmacogenomics in colorectal cancer: A genome-wide association study to predict toxicity after 5-fluorouracil or FOLFOX administration |
| title_sort | pharmacogenomics in colorectal cancer a genome wide association study to predict toxicity after 5 fluorouracil or folfox administration |
| work_keys_str_mv | AT fernandezrozadillac pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT cazierj pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT morenov pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT crousboum pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT guinoe pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT durang pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT lamasm pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT lopezr pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT candamios pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT gallardoe pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT parel pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT baigetm pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT paezd pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT lopezfernandezl pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT cortejosol pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT garciam pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT bujandal pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT gonzalezd pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT gonzalov pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT rodrigol pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT renej pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT joverr pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT breafernandeza pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT andreum pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration AT bessax pharmacogenomicsincolorectalcanceragenomewideassociationstudytopredicttoxicityafter5fluorouracilorfolfoxadministration |