Transcriptomic perspectives on neocortical structure, development, evolution, and disease
The cerebral cortex is the source of our most complex cognitive capabilities and a vulnerable target of many neurological and neuropsychiatric disorders. Transcriptomics offers a new approach to understanding the cortex at the level of its underlying genetic code, and rapid technological advances ha...
| Autori principali: | , , , |
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| Natura: | Journal article |
| Lingua: | English |
| Pubblicazione: |
Annual Reviews
2017
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| _version_ | 1826265870211481600 |
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| author | Lein, E Belgard, T Hawrylycz, M Molnár, Z |
| author_facet | Lein, E Belgard, T Hawrylycz, M Molnár, Z |
| author_sort | Lein, E |
| collection | OXFORD |
| description | The cerebral cortex is the source of our most complex cognitive capabilities and a vulnerable target of many neurological and neuropsychiatric disorders. Transcriptomics offers a new approach to understanding the cortex at the level of its underlying genetic code, and rapid technological advances have propelled this field to the high-throughput study of the complete set of transcribed genes at increasingly fine resolution to the level of individual cells. These tools have revealed features of the genetic architecture of adult cortical areas, layers, and cell types, as well as spatiotemporal patterning during development. This has allowed a fresh look at comparative anatomy as well, illustrating surprisingly large differences between mammals while at the same time revealing conservation of some features from avians to mammals. Finally, transcriptomics is fueling progress in understanding the causes of neurodevelopmental diseases such as autism, linking genetic association studies to specific molecular pathways and affected brain regions. |
| first_indexed | 2024-03-06T20:30:23Z |
| format | Journal article |
| id | oxford-uuid:30d777c8-1d19-4181-b181-e52ca2a8b8f1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:30:23Z |
| publishDate | 2017 |
| publisher | Annual Reviews |
| record_format | dspace |
| spelling | oxford-uuid:30d777c8-1d19-4181-b181-e52ca2a8b8f12022-03-26T13:04:05ZTranscriptomic perspectives on neocortical structure, development, evolution, and diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:30d777c8-1d19-4181-b181-e52ca2a8b8f1EnglishSymplectic Elements at OxfordAnnual Reviews2017Lein, EBelgard, THawrylycz, MMolnár, ZThe cerebral cortex is the source of our most complex cognitive capabilities and a vulnerable target of many neurological and neuropsychiatric disorders. Transcriptomics offers a new approach to understanding the cortex at the level of its underlying genetic code, and rapid technological advances have propelled this field to the high-throughput study of the complete set of transcribed genes at increasingly fine resolution to the level of individual cells. These tools have revealed features of the genetic architecture of adult cortical areas, layers, and cell types, as well as spatiotemporal patterning during development. This has allowed a fresh look at comparative anatomy as well, illustrating surprisingly large differences between mammals while at the same time revealing conservation of some features from avians to mammals. Finally, transcriptomics is fueling progress in understanding the causes of neurodevelopmental diseases such as autism, linking genetic association studies to specific molecular pathways and affected brain regions. |
| spellingShingle | Lein, E Belgard, T Hawrylycz, M Molnár, Z Transcriptomic perspectives on neocortical structure, development, evolution, and disease |
| title | Transcriptomic perspectives on neocortical structure, development, evolution, and disease |
| title_full | Transcriptomic perspectives on neocortical structure, development, evolution, and disease |
| title_fullStr | Transcriptomic perspectives on neocortical structure, development, evolution, and disease |
| title_full_unstemmed | Transcriptomic perspectives on neocortical structure, development, evolution, and disease |
| title_short | Transcriptomic perspectives on neocortical structure, development, evolution, and disease |
| title_sort | transcriptomic perspectives on neocortical structure development evolution and disease |
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