Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit.

Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit.

Hypoxia-inducible factor-1 (HIF-1), a heterodimeric DNA binding complex composed of two basic-helix-loop-helix Per-AHR-ARNT-Sim proteins (HIF-1alpha and -1beta), is a key component of a widely operative transcriptional response activated by hypoxia, cobaltous ions, and iron chelation. To identify re...

Полное описание

Библиографические подробности
Главные авторы:	Pugh, C, O'Rourke, J, Nagao, M, Gleadle, J, Ratcliffe, P
Формат:	Journal article
Язык:	English
Опубликовано:	1997

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