Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit.

Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit.

Hypoxia-inducible factor-1 (HIF-1), a heterodimeric DNA binding complex composed of two basic-helix-loop-helix Per-AHR-ARNT-Sim proteins (HIF-1alpha and -1beta), is a key component of a widely operative transcriptional response activated by hypoxia, cobaltous ions, and iron chelation. To identify re...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Pugh, C, O'Rourke, J, Nagao, M, Gleadle, J, Ratcliffe, P
التنسيق:	Journal article
اللغة:	English
منشور في:	1997

مواد مشابهة

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Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor.
حسب: Appelhoff, R, وآخرون
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Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia.
حسب: Sowter, H, وآخرون
منشور في: (2003)

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Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms.
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Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.
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Suppression of collagen IV alpha‐2 subunit by prolyl hydroxylase domain inhibition via hypoxia‐inducible factor‐1 in chronic kidney disease
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منشور في: (2021-10-01)

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New horizons in hypoxia signaling pathways
حسب: Pugh, C, وآخرون
منشور في: (2017)

Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis.
حسب: Lakhal, S, وآخرون
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Regulation of angiogenesis by hypoxia: role of the HIF system.
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