Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit.

Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit.

Hypoxia-inducible factor-1 (HIF-1), a heterodimeric DNA binding complex composed of two basic-helix-loop-helix Per-AHR-ARNT-Sim proteins (HIF-1alpha and -1beta), is a key component of a widely operative transcriptional response activated by hypoxia, cobaltous ions, and iron chelation. To identify re...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Pugh, C, O'Rourke, J, Nagao, M, Gleadle, J, Ratcliffe, P
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	1997

Ижил төстэй зүйлс

Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.
-н: O'Rourke, J, зэрэг
Хэвлэсэн: (1999)

Hypoxia response elements.
-н: O'Rourke, J, зэрэг
Хэвлэсэн: (1997)

Induction of hypoxia-inducible factor-1, erythropoietin, vascular endothelial growth factor, and glucose transporter-1 by hypoxia: evidence against a regulatory role for Src kinase.
-н: Gleadle, J, зэрэг
Хэвлэсэн: (1997)

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.
-н: Pollard, P, зэрэг
Хэвлэсэн: (2008)

Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression.
-н: Ratcliffe, P, зэрэг
Хэвлэсэн: (1998)

Identification of hypoxically inducible mRNAs in HeLa cells using differential-display PCR. Role of hypoxia-inducible factor-1.
-н: O'Rourke, J, зэрэг
Хэвлэсэн: (1996)

Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression.
-н: Wood, S, зэрэг
Хэвлэсэн: (1998)

Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts.
-н: Mole, D, зэрэг
Хэвлэсэн: (2009)

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation.
-н: Masson, N, зэрэг
Хэвлэсэн: (2001)

Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: similarities with the regulation of erythropoietin.
-н: Ebert, B, зэрэг
Хэвлэсэн: (1996)

Hypoxia-inducible factors: where, when and why?
-н: Gleadle, J, зэрэг
Хэвлэсэн: (2006)

Regulation of the Drosophila bHLH-PAS protein Sima by hypoxia: functional evidence for homology with mammalian HIF-1 alpha.
-н: Bacon, N, зэрэг
Хэвлэсэн: (1998)

Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.
-н: Wiesener, MS, зэрэг
Хэвлэсэн: (1998)

Hypoxia and the regulation of gene expression.
-н: Gleadle, J, зэрэг
Хэвлэсэн: (1998)

Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.
-н: Mole, D, зэрэг
Хэвлэсэн: (2002)

Hypoxia and oxidative stress in breast cancer. Hypoxia signalling pathways.
-н: Pugh, C, зэрэг
Хэвлэсэн: (2001)

Oxygen regulated gene expression: erythropoietin as a model system.
-н: Ratcliffe, P, зэрэг
Хэвлэсэн: (1997)

MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH).
-н: Webb, J, зэрэг
Хэвлэсэн: (2009)

The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha.
-н: Willam, C, зэрэг
Хэвлэсэн: (2004)

Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways.
-н: Elvidge, G, зэрэг
Хэвлэсэн: (2006)

Calcineurin B-like domains in the large regulatory alpha/beta subunits of phosphorylase kinase.
-н: Carrière, C, зэрэг
Хэвлэсэн: (2008)

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor.
-н: Appelhoff, R, зэрэг
Хэвлэсэн: (2004)

Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia.
-н: Sowter, H, зэрэг
Хэвлэсэн: (2003)

Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].
-н: Stolze, I, зэрэг
Хэвлэсэн: (2004)

Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms.
-н: Lau, K, зэрэг
Хэвлэсэн: (2007)

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.
-н: Elkins, J, зэрэг
Хэвлэсэн: (2003)

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.
-н: Maxwell, P, зэрэг
Хэвлэсэн: (1997)

The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.
-н: Talks, K, зэрэг
Хэвлэсэн: (2000)

Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents.
-н: Gleadle, J, зэрэг
Хэвлэсэн: (1995)

Suppression of collagen IV alpha‐2 subunit by prolyl hydroxylase domain inhibition via hypoxia‐inducible factor‐1 in chronic kidney disease
-н: Mohammad Sanaei‐Ardekani, зэрэг
Хэвлэсэн: (2021-10-01)

Expression of hypoxia-inducible factors-1alpha and-2alpha in hypoxic and ischemic rat kidneys
-н: Rosenberger, C, зэрэг
Хэвлэсэн: (2002)

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.
-н: Cockman, M, зэрэг
Хэвлэсэн: (2000)

Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys.
-н: Rosenberger, C, зэрэг
Хэвлэсэн: (2002)

Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia. Implications for the mechanism of oxygen sensing.
-н: Gleadle, J, зэрэг
Хэвлэсэн: (1995)

The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.
-н: Pugh, C, зэрэг
Хэвлэсэн: (2003)

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.
-н: Wiesener, MS, зэрэг
Хэвлэсэн: (2003)

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
-н: Hewitson, K, зэрэг
Хэвлэсэн: (2002)

New horizons in hypoxia signaling pathways
-н: Pugh, C, зэрэг
Хэвлэсэн: (2017)

Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis.
-н: Lakhal, S, зэрэг
Хэвлэсэн: (2011)

Regulation of angiogenesis by hypoxia: role of the HIF system.
-н: Pugh, C, зэрэг
Хэвлэсэн: (2003)